Department of General and Trauma Surgery, BG University Hospital Bergmannsheil, Bochum, Germany.
Department of Pain Medicine, BG University Hospital Bergmannsheil, Bochum, Germany.
PLoS One. 2018 Nov 12;13(11):e0207122. doi: 10.1371/journal.pone.0207122. eCollection 2018.
Osteoporosis remains a major health concern due to high incidence of fragility fractures followed by higher mortality and morbidity. Implementation of guidelines for diagnosis and treatment of osteoporosis is critically discussed internationally. Aim of this study was to evaluate implementation of these guidelines regarding diagnosis and therapy of osteoporosis in a developed western country. We hypothesized that (a) prior diagnosis of osteoporosis in patients with low-energy fractures is higher than the estimated incidence and (b) diagnosis and therapy of osteoporosis in patients with prior low-energy fractures is higher than in patients without prior low-energy fractures. 399 patients >60 years suffering low-energy-fractures of their spine, femur, humerus or forearm between 03/2014 and 04/2015 were recruited in a German trauma center. All received a standardized interview. In 21% (84/399) of all patients, osteoporosis was diagnosed prior to current admission. 34% (136/399) suffered a prior risk-fracture after age of 50. Of these, only 54% (73/136) reported about following dual-energy X-ray absorptiometry (DXA) to test for decreased bone-marrow-density with positive results in 68% (50/73). 38% (19/50) of these patients with fragility fractures and prior osteoporosis diagnosis received anti-osteoporotic medication. 66% (263/399) of all patients had no prior risk-fracture and were tested for osteoporosis by DXA in 36% (95/263), leading to positive results in 34% (32/95). 44% (14/32) of these patients received anti-osteoporotic medication. Applying FRAX, 33% of all patients showed a calculated 10-year-risk >20% for suffering a major osteoporotic fracture. 61% (83/136) of patients with a prior fracture had a 10-year-risk >20% of which 47% (39/83) patients received no prior DXA. Although guidelines recommend diagnosis and treatment of patients with low-energy fractures, opportunity for early treatment following risk fractures seems rarely used. Expedient risk assessment is necessary to indicate further diagnostics and therapy of osteoporosis to ensure adequate and efficient treatment for osteoporotic fractures.
骨质疏松症仍然是一个主要的健康问题,因为脆性骨折的发生率较高,随之而来的死亡率和发病率也较高。国际上对骨质疏松症的诊断和治疗指南的实施进行了批判性的讨论。本研究的目的是评估在一个发达的西方国家,这些指南在骨质疏松症的诊断和治疗中的实施情况。我们假设:(a)低能量骨折患者的骨质疏松症诊断率高于估计的发病率;(b)低能量骨折患者的骨质疏松症诊断和治疗率高于无低能量骨折史的患者。2014 年 3 月至 2015 年 4 月期间,在一家德国创伤中心招募了 399 名年龄在 60 岁以上、患有脊柱、股骨、肱骨或前臂低能量骨折的患者。所有患者均接受了标准化的访谈。在所有患者中,21%(84/399)在本次入院前被诊断为骨质疏松症。34%(136/399)在 50 岁后发生过先前的风险性骨折。其中,只有 54%(73/136)报告进行了双能 X 线吸收法(DXA)检查以检测骨密度降低,结果阳性率为 68%(50/73)。50 例脆性骨折且有先前骨质疏松症诊断的患者中,有 38%(19/50)接受了抗骨质疏松药物治疗。所有患者中,66%(263/399)无先前的风险性骨折,36%(95/263)接受了 DXA 检查,结果阳性率为 34%(32/95)。这些患者中有 44%(14/32)接受了抗骨质疏松药物治疗。应用 FRAX 评估,所有患者中有 33%的 10 年骨折风险>20%,有脆性骨折史的患者中有 61%(83/136)的 10 年骨折风险>20%,其中 47%(39/83)的患者之前未行 DXA 检查。尽管指南建议对低能量骨折患者进行诊断和治疗,但对风险性骨折后早期治疗的机会似乎很少利用。有必要进行快速风险评估,以确定是否需要进一步的骨质疏松症诊断和治疗,以确保对骨质疏松性骨折进行充分和有效的治疗。