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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Rusakov Y I, Karasev V S, Bondareva V M, Pertseva M N, Pankov Y A

Sechenov Institute of Evolutionary Physiology and Biochemistry, USSR Academy of Sciences, Leningrad.

Comp Biochem Physiol B. 1990;95(3):477-82. doi: 10.1016/0305-0491(90)90006-f.

Insulins have been isolated from islet tissue of pink (Oncorhynchus gorbuscha) and chum (Oncorhynchus keta) salmon. The primary structure of chum and pink salmon insulins was found to be identical. Compared to the amino acid sequence of human insulin, the salmon insulins under study differed at 14 positions. 2. Biological activity of pink salmon insulin was 83% of that of standard porcine insulin. 3. The immunological properties of fish insulins were investigated in specific radioimmunoassay (RIA) systems, based on porcine and pink salmon insulins. 4. A significant difference in the antigenic determinants of these fish and mammalian hormones was revealed.

胰岛素已从粉鲑（驼背大麻哈鱼）和狗鲑（大麻哈鱼）的胰岛组织中分离出来。已发现狗鲑和粉鲑胰岛素的一级结构相同。与人类胰岛素的氨基酸序列相比，所研究的鲑鱼胰岛素在14个位置上有所不同。2. 粉鲑胰岛素的生物活性为标准猪胰岛素的83%。3. 在基于猪胰岛素和粉鲑胰岛素的特定放射免疫分析（RIA）系统中研究了鱼类胰岛素的免疫特性。4. 揭示了这些鱼类和哺乳动物激素抗原决定簇的显著差异。

Rusakov Y I, Karasev V S, Bondareva V M, Pertseva M N, Pankov Y A

Sechenov Institute of Evolutionary Physiology and Biochemistry, USSR Academy of Sciences, Leningrad.

Comp Biochem Physiol B. 1990;95(3):477-82. doi: 10.1016/0305-0491(90)90006-f.

Insulins have been isolated from islet tissue of pink (Oncorhynchus gorbuscha) and chum (Oncorhynchus keta) salmon. The primary structure of chum and pink salmon insulins was found to be identical. Compared to the amino acid sequence of human insulin, the salmon insulins under study differed at 14 positions. 2. Biological activity of pink salmon insulin was 83% of that of standard porcine insulin. 3. The immunological properties of fish insulins were investigated in specific radioimmunoassay (RIA) systems, based on porcine and pink salmon insulins. 4. A significant difference in the antigenic determinants of these fish and mammalian hormones was revealed.

胰岛素已从粉鲑（驼背大麻哈鱼）和狗鲑（大麻哈鱼）的胰岛组织中分离出来。已发现狗鲑和粉鲑胰岛素的一级结构相同。与人类胰岛素的氨基酸序列相比，所研究的鲑鱼胰岛素在14个位置上有所不同。2. 粉鲑胰岛素的生物活性为标准猪胰岛素的83%。3. 在基于猪胰岛素和粉鲑胰岛素的特定放射免疫分析（RIA）系统中研究了鱼类胰岛素的免疫特性。4. 揭示了这些鱼类和哺乳动物激素抗原决定簇的显著差异。