Herman A, Ron-El R, Golan A, Nahum H, Soffer Y, Caspi E
Department of Obstetrics and Gynecology, Assaf Harofe Medical Centre, Zerifin, Israel.
Fertil Steril. 1990 May;53(5):854-8. doi: 10.1016/s0015-0282(16)53521-3.
The incidence and behavior of follicle cysts after different timing of gonadotropin-releasing hormone analog (GnRH-a) administration was studied in 321 in vitro fertilization (IVF) cycles. Group M included 198 cycles in which GnRH-a was injected at menstruation. Of these, 171 (88.6%) were without cysts (group M1) and 27 (13.6%) with cysts (group M2). Group L comprised of 123 cycles in which GnRH-a was administered in the midluteal phase. Of them, 70 (56.9%) were without cystic finding (group L1), 19 (15.4%) with follicle cysts (group L2), and 34 cases (27.6%) with visible corpus luteum at the time of GnRH-a initiation (group L3). Both groups with follicle cysts demonstrated a higher luteinizing hormone peak and continuous elevated estradiol (E2) levels. In group M2, the E2 rise and the cysts persisted longer compared with group L2. Gonadotropin treatment was accordingly postponed until the cysts regressed spontaneously. Only two cases of group M2 required aspiration of the cysts. Follicle cyst formation is not related to the timing of GnRH-a administration and their occurrence did not have adverse effects on IVF outcome.
在321个体外受精（IVF）周期中，研究了不同时间给予促性腺激素释放激素类似物（GnRH-a）后卵泡囊肿的发生率及表现。M组包括198个周期，其中GnRH-a在月经时注射。其中，171个周期（88.6%）无囊肿（M1组），27个周期（13.6%）有囊肿（M2组）。L组包括123个周期，其中GnRH-a在黄体中期给药。其中，70个周期（56.9%）无囊肿发现（L1组），19个周期（15.4%）有卵泡囊肿（L2组），34例（27.6%）在GnRH-a开始使用时可见黄体（L3组）。两组有卵泡囊肿的患者均表现出较高的促黄体生成素峰值和持续升高的雌二醇（E2）水平。M2组与L2组相比，E2升高和囊肿持续时间更长。因此，促性腺激素治疗推迟至囊肿自发消退。M2组仅2例需要抽吸囊肿。卵泡囊肿的形成与GnRH-a给药时间无关，其发生对IVF结局无不良影响。
