Tarlatzis B C, Bili H, Bontis J, Lagos S, Vatev I, Mantalenakis S
1st Department of Obstetrics and Gynaecology, Aristotle University of Thessaloniki, Greece.
Hum Reprod. 1994 Nov;9(11):1983-6. doi: 10.1093/oxfordjournals.humrep.a138378.
The aim of this study was to examine the occurrence of ovarian cysts during the administration of three different gonadotrophin-releasing hormone analogues (GnRHa) in the long protocol as well as their characteristics, management and outcome compared with patients with no cyst formation. A total of 172 in-vitro fertilization (IVF) cycles in which GnRHa was administered at menstruation were analysed. Group B consisted of 72 cycles in which buserelin was used. Of these, 10 (13.9%) were with cysts (group B1) and 62 (86.1%) without cysts (group B2). Group T included 49 cycles in which triptorelin was injected. Of these, seven (14.2%) were with cysts (group T1) and 42 (85.7%) without cysts (group T2). Group L comprised 51 cycles in which leuprolide was administered. Of these, eight (15.7%) were with cysts (group L1) and 43 (84.3%) without cysts (group L2). All women with ovarian cysts had higher serum oestradiol concentrations and all except five underwent cyst aspiration with no complication. No differences were observed in the number of follicles and oocytes between groups B, T and L or between the groups with cysts and those without cysts. The pregnancy rate was similar in all groups. In conclusion, follicle cyst formation does not seem to be related to the use of a specific GnRHa, its short- or long-acting form or to the mode of administration. In addition, follicle cyst aspiration is a safe and successful solution to the problem of functionally active ovarian cysts.
本研究的目的是探讨在长方案中使用三种不同促性腺激素释放激素类似物（GnRHa）期间卵巢囊肿的发生情况，以及与未形成囊肿的患者相比，其特征、处理方法和结局。共分析了172个在月经周期使用GnRHa的体外受精（IVF）周期。B组包括72个使用布舍瑞林的周期。其中，10个（13.9%）出现囊肿（B1组），62个（86.1%）未出现囊肿（B2组）。T组包括49个注射曲普瑞林的周期。其中，7个（14.2%）出现囊肿（T1组），42个（85.7%）未出现囊肿（T2组）。L组包括51个使用亮丙瑞林的周期。其中，8个（15.7%）出现囊肿（L1组），43个（84.3%）未出现囊肿（L2组）。所有患有卵巢囊肿的女性血清雌二醇浓度均较高，除5例患者外，其余均接受了囊肿穿刺抽吸，无并发症发生。B、T和L组之间以及有囊肿组和无囊肿组之间在卵泡和卵母细胞数量上未观察到差异。所有组的妊娠率相似。总之，卵泡囊肿的形成似乎与特定GnRHa的使用、其短效或长效形式或给药方式无关。此外，卵泡囊肿穿刺抽吸是解决功能性活跃卵巢囊肿问题的一种安全且成功的方法。
