Geisthövel F, Peters F, Breckwoldt M
Arch Gynecol. 1985;236(4):255-9. doi: 10.1007/BF02133944.
Pulsatile long-term gonadotropin releasing hormone (GnRH) therapy with an average dosage of 8 micrograms/pulse i.v. in intervals of 90 min induced in a patient with hypothalamic amenorrhea the development of multiple ovarian cysts as visualized by ultrasonography. Estradiol (E2) plasma concentration reached values of 5000 pg/ml. These findings indicate that pulsatile GnRH application can induce ovarian hyperstimulation.
对一名下丘脑性闭经患者进行长期脉冲式促性腺激素释放激素（GnRH）治疗，平均静脉注射剂量为8微克/脉冲，间隔90分钟，超声检查显示诱发了多个卵巢囊肿的形成。血浆雌二醇（E2）浓度达到5000 pg/ml。这些发现表明，脉冲式应用GnRH可诱发卵巢过度刺激。
