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Effect of diabetes and time after in vivo insulin administration on ketogenesis and gluconeogenesis in isolated rat hepatocytes.

作者信息

Kaloyianni M, Freedland R A

机构信息

Laboratory of Animal Physiology, Science School, Aristotelian University of Thessaloniki, Greece.

出版信息

Int J Biochem. 1990;22(2):159-64. doi: 10.1016/0020-711x(90)90178-6.

DOI:10.1016/0020-711x(90)90178-6
PMID:2185062
Abstract
  1. Diabetic rats had elevated rates of gluconeogenesis and ketone body production. 2. Four hours after insulin administration the rate of gluconeogenesis returned to normal and the rate of ketogenesis decreased with certain substrates, but did not return to normal. 3. Eight hours after insulin treatment ketogenesis from all substrates was significantly reduced, but still significantly higher than normal.
摘要

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1
Effect of diabetes and time after in vivo insulin administration on ketogenesis and gluconeogenesis in isolated rat hepatocytes.
Int J Biochem. 1990;22(2):159-64. doi: 10.1016/0020-711x(90)90178-6.
2
Studies on gluconeogenesis and ketogenesis in isolated hepatocytes from alloxan diabetic rats.对四氧嘧啶糖尿病大鼠分离肝细胞中糖异生和生酮作用的研究。
Proc Soc Exp Biol Med. 1975 Dec;150(3):786-90. doi: 10.3181/00379727-150-39125.
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The effects of pyruvate concentration, dichloroacetate and alpha-cyano-4-hydroxycinnamate on gluconeogenesis, ketogenesis and [3-hydroxybutyrate]/[3-oxobutyrate] ratios in isolated rat hepatocytes.丙酮酸浓度、二氯乙酸和α-氰基-4-羟基肉桂酸对分离的大鼠肝细胞糖异生、酮体生成及[3-羟基丁酸]/[3-氧代丁酸]比值的影响。
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Effect of tolazamide on basal ketogenesis, glycogenesis, and gluconeogenesis in liver obtained from normal and diabetic rats.
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Control mechanisms of gluconeogenesis and ketogenesis. II. Interactions between fatty acid oxidation and the citric acid cycle in perfused rat liver.糖异生和酮体生成的调控机制。II. 灌注大鼠肝脏中脂肪酸氧化与柠檬酸循环之间的相互作用。
J Biol Chem. 1969 Sep 10;244(17):4617-27.
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Lipogenesis from ketone bodies in perfused livers from streptozocin-induced diabetic rats.链脲佐菌素诱导的糖尿病大鼠灌注肝脏中酮体的脂肪生成
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Effect of insulin in vitro on the isolated, perfused alloxan-diabetic rat liver.胰岛素在体外对四氧嘧啶糖尿病大鼠离体灌注肝脏的作用。
Diabetologia. 1978 Jan 14;14(1):47-51. doi: 10.1007/BF00429707.
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[Gluconeogenesis, ketogenesis, and ureogenesis in isolated hepatocytes from diabetic rats: effects of insulin].[糖尿病大鼠分离肝细胞中的糖异生、酮体生成和尿素生成:胰岛素的作用]
Ann Nutr Metab. 1986;30(2):129-36. doi: 10.1159/000177185.
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Effects of tolbutamide on fructose-2,6-bisphosphate formation and ketogenesis in hepatocytes from diabetic rats.甲苯磺丁脲对糖尿病大鼠肝细胞中果糖-2,6-二磷酸生成及酮体生成的影响。
Metabolism. 1992 Jul;41(7):706-10. doi: 10.1016/0026-0495(92)90308-w.

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Role of insulin in hepatic fatty acid partitioning: emerging concepts.胰岛素在肝脏脂肪酸分配中的作用:新出现的概念
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Effects of insulin treatment of diabetic rats on hepatic partitioning of fatty acids between oxidation and esterification, phospholipid and acylglycerol synthesis, and on the fractional rate of secretion of triacylglycerol in vivo.
胰岛素治疗糖尿病大鼠对脂肪酸在氧化与酯化之间的肝脏分配、磷脂和酰基甘油合成以及体内三酰甘油分泌分数率的影响。
Biochem J. 1994 Nov 15;304 ( Pt 1)(Pt 1):177-82. doi: 10.1042/bj3040177.
4
Insulin-independent and extremely rapid switch in the partitioning of hepatic fatty acids from oxidation to esterification in starved-refed diabetic rats. Possible roles for changes in cell pH and volume.饥饿再喂养的糖尿病大鼠肝脏脂肪酸分配从氧化到酯化的胰岛素非依赖性且极其快速的转变。细胞pH值和体积变化的可能作用。
Biochem J. 1995 Feb 1;305 ( Pt 3)(Pt 3):953-8. doi: 10.1042/bj3050953.