Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Semin Diagn Pathol. 2011 Aug;28(3):245-55. doi: 10.1053/j.semdp.2011.02.010.
Mantle cell lymphoma (MCL; previously called centrocytic lymphoma or lymphocytic lymphoma of intermediate differentiation) is a distinct subtype of B-cell lymphoma, accounting for approximately 3%-10% of all lymphoma diagnoses. The name refers to the growth pattern in early disease presentation resembling the normal mantle zone that surrounds the germinal center of the B-cell follicle. The hallmark of MCL is the t(11;14)(q13;q32), resulting in aberrant expression of the CCND1 gene and expression of cyclin D1 in the tumor cells. Expression and genomic profiling of MCL have provided new insight into the pathogenesis and will be summarized in this review. Pitfalls in the differential diagnosis versus B-cell chronic lymphocytic leukemia, B-cell prolymphocytic leukemia, cyclin D1-positive diffuse large B-cell lymphoma, hairy cell leukemia, and plasma cell tumors will be discussed, including the usefulness new diagnostic markers SOX11 and CD200. In situ MCL, MCL with an indolent clinical course, and cyclin D1-negative MCL are other topics of this review.
套细胞淋巴瘤（MCL；以前称为中心细胞淋巴瘤或中等分化的淋巴细胞淋巴瘤）是 B 细胞淋巴瘤的一个独特亚型，约占所有淋巴瘤诊断的 3%-10%。这个名称指的是早期疾病表现的生长模式类似于围绕 B 细胞滤泡生发中心的正常套区。MCL 的标志是 t(11;14)(q13;q32)，导致 CCND1 基因异常表达和肿瘤细胞中环素 D1 的表达。MCL 的表达和基因组分析为发病机制提供了新的见解，这将在本综述中进行总结。本文将讨论与 B 细胞慢性淋巴细胞白血病、B 细胞幼淋巴细胞白血病、cyclin D1 阳性弥漫性大 B 细胞淋巴瘤、毛细胞白血病和浆细胞瘤的鉴别诊断中的陷阱，包括新的诊断标志物 SOX11 和 CD200 的用途。原位 MCL、临床过程惰性的 MCL 和 cyclin D1 阴性的 MCL 是本综述的其他主题。
