Chen Binghai, Yin Guangming, Duan Lujing, Li Wanmeng, Jiang Xianzhen
Department of Urology, Third Xiang-Ya Hospital of Central South University, Yuelu, Changsha 410000.
Oncol Lett. 2012 Aug;4(2):265-267. doi: 10.3892/ol.2012.732. Epub 2012 May 25.
Mantle cell lymphoma (MCL) of the prostate, either primary or secondary, is a rare entity. This case report examines an 83-year-old male who complained of not only nocturia (2-3 times), but also frequency and urgency of urination. The maximal urinary flow rate was 4.1 ml/sec. A transrectal ultrasound-guided prostate biopsy was advised after a hard enlargement of the prostate was detected; however, it was refused. Therefore, a plasma kinetic transurethral resection of the prostate was performed. Postoperative pathological examinations demonstrated MCL of the prostate. Positive immunohistochemistry for CD5 and cyclin D1 was observed. The diagnosis was confirmed by the introduction of a new diagnostic marker, SOX11. The maximal flow rate achieved was 15 ml/sec following surgery. To the best of our knowledge, this is the first study of MCL being diagnosed using SOX11 as a marker in the prostate. This case should alert clinicians and pathologists to pay close attention to the diagnosis of malignant lymphoma of the prostate. This study provides further insights into the diagnosis and therapy of MCL.
前列腺套细胞淋巴瘤（MCL），无论是原发性还是继发性，都是一种罕见的疾病。本病例报告研究了一名83岁男性，他不仅主诉夜尿（2 - 3次），还伴有尿频和尿急。最大尿流率为4.1毫升/秒。在检测到前列腺质地变硬增大后，建议进行经直肠超声引导下的前列腺活检；然而，患者拒绝了。因此，进行了等离子体动力学经尿道前列腺切除术。术后病理检查显示为前列腺MCL。观察到CD5和细胞周期蛋白D1免疫组化呈阳性。通过引入一种新的诊断标志物SOX11确诊。术后最大尿流率达到了15毫升/秒。据我们所知，这是首次使用SOX11作为标志物诊断前列腺MCL的研究。该病例应提醒临床医生和病理学家密切关注前列腺恶性淋巴瘤的诊断。本研究为MCL的诊断和治疗提供了进一步的见解。
