Department of Applied Chemistry, School of Advanced Science and Engineering, Waseda University, Shinjuku-ku, Tokyo, Japan.
J Med Chem. 2011 Sep 22;54(18):6295-304. doi: 10.1021/jm200662c. Epub 2011 Aug 26.
To determine the effects of a [6]-gingerol analogue (6G), a major chemical component of the ginger rhizome, and its stable analogue after digestion in simulated gastric fluid, aza-[6]-gingerol (A6G), on diet-induced body fat accumulation, we synthesized 6G and A6G. Mice were fed either a control regular rodent chow, a high-fat diet (HFD), or a HFD supplemented with 6G and A6G. Magnetic resonance imaging adiposity parameters of the 6G- and A6G-treated mice were compared with those of control mice. Supplementation with 6G and A6G significantly reduced body weight gain, fat accumulation, and circulating levels of insulin and leptin. The mRNA levels of sterol regulatory element-binding protein 1c (SREBP-1c) and acetyl-CoA carboxylase 1 in the liver were significantly lower in mice fed A6G than in HFD control mice. Our findings indicate that A6G, rather than 6G, enhances energy metabolism and reduces the extent of lipogenesis by downregulating SREBP-1c and its related molecules, which leads to the suppression of body fat accumulation.
为了确定[6]-姜烯酚类似物（6G），生姜根茎中的主要化学成分，及其在模拟胃液消化后的稳定类似物氮杂-[6]-姜烯酚（A6G）对饮食诱导的体脂肪积累的影响，我们合成了 6G 和 A6G。将小鼠分别喂食对照常规啮齿动物饲料、高脂肪饮食（HFD）或补充 6G 和 A6G 的 HFD。比较了 6G 和 A6G 处理的小鼠的磁共振成像肥胖参数与对照小鼠的参数。补充 6G 和 A6G 可显著减少体重增加、脂肪积累和循环胰岛素和瘦素水平。与 HFD 对照组相比，A6G 喂养的小鼠肝脏中固醇调节元件结合蛋白 1c（SREBP-1c）和乙酰辅酶 A 羧化酶 1 的 mRNA 水平明显降低。我们的研究结果表明，A6G 而不是 6G 通过下调 SREBP-1c 及其相关分子增强能量代谢并减少脂肪生成的程度，从而抑制体脂肪积累。
