Instituto de Nutrigenética y Nutrigenómica Traslacional, Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, México.
Doctorado en Ciencias de la Nutrición Traslacional, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, México.
Adipocyte. 2024 Dec;13(1):2411453. doi: 10.1080/21623945.2024.2411453. Epub 2024 Oct 10.
Obesity is a globally prevalent metabolic disorder characterized by an increased number of adipose cells and excessive fat in adipocytes. Herbal medicines, such as ginger, have shown potential in treating obesity by inhibiting adipogenesis and reducing adipocyte hypertrophy. Ginger contains bioactive compounds, particularly gingerols, which have demonstrated anti-adipogenic and/or lipolytic effects. However, research on the effects of 10-gingerol on adipose tissue remains limited. This study aimed to evaluate the effect of 10-gingerol on lipid content, lipolysis markers, and the expression of genes related to lipid metabolism in 3T3-L1 adipocytes. Three groups were analyzed: a negative control (preadipocytes), a positive control (mature adipocytes), and a group treated with 10-gingerol (10-G). Results showed that 10-G reduced lipid accumulation by 42.16% in mature adipocytes compared to the control, without affecting cell viability. Additionally, 10-G increased glycerol release and downregulated lipogenic genes such as , and , while upregulating genes related to fatty acid oxidation, including , and . In conclusion, 10-gingerol reduces lipid content in mature adipocytes by downregulating lipogenesis, increasing lipolysis, and enhancing fatty acid oxidation.
肥胖是一种全球流行的代谢紊乱症，其特征是脂肪细胞数量增加和脂肪细胞内脂肪过多。草药，如姜，已显示出通过抑制脂肪生成和减少脂肪细胞肥大来治疗肥胖的潜力。姜含有生物活性化合物，特别是姜辣素，具有抗脂肪生成和/或脂肪分解作用。然而，关于 10-姜酚对脂肪组织影响的研究仍然有限。本研究旨在评估 10-姜酚对 3T3-L1 脂肪细胞中脂质含量、脂肪分解标志物以及与脂质代谢相关基因表达的影响。分析了三组：阴性对照组（前脂肪细胞）、阳性对照组（成熟脂肪细胞）和 10-姜酚处理组（10-G）。结果表明，与对照组相比，10-G 使成熟脂肪细胞中的脂质积累减少了 42.16%，而不影响细胞活力。此外，10-G 增加了甘油的释放，并下调了脂肪生成基因如、和，同时上调了与脂肪酸氧化相关的基因，包括、和。总之，10-姜酚通过下调脂肪生成、增加脂肪分解和增强脂肪酸氧化来减少成熟脂肪细胞中的脂质含量。
