君迁子在动物体内的解热和镇痛活性。
Antipyretic and antinociceptive activity of Diospyros lotus L. in animals.
作者信息
Rauf Abdur, Uddin Ghias, Siddiqui Bina S, Muhammad Naveed, Khan Haroon
机构信息
Institute of Chemical Sciences, University of Peshawar, Peshawar-25120, KPK, Pakistan.
H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan.
出版信息
Asian Pac J Trop Biomed. 2014 May;4(Suppl 1):S382-6. doi: 10.12980/APJTB.4.2014C1020.
Abstract
OBJECTIVE
To evaluate pharmacologically the traditional use of Diospyros lotus as antipyretic and antinociceptive in various animal models.
METHODS
In vivo experimental models were used in this study. Antipyretic activity of extract/fractions was evaluated in brewer's yeast induced hyperthermic mice while antinociceptive activity was studied in acetic acid induced writhing test at 50 and 100 mg/kg i.p.
RESULTS
The crude extract strongly ameliorated the induced pyrexia during various assessment times. Upon fractionation, the antipyretic effects were strongly augmented by the chloroform and ethyl acetate fractions of the plant. However, hexane and butanol fractions were insignificant in their effect as antipyretic. The extract showed marked inhibition on the noxious simulation induced by post acetic acid injection. The effect was strongly supported by other fraction expect hexane.
CONCLUSIONS
In short, our study scientifically validated the traditional use of the plant as antipyretic.
摘要
目的
通过药理学方法评估传统上使用的君迁子在各种动物模型中的解热和镇痛作用。
方法
本研究采用体内实验模型。提取物/馏分的解热活性在啤酒酵母诱导的发热小鼠中进行评估，而镇痛活性则在腹腔注射50和100mg/kg的醋酸诱导扭体试验中进行研究。
结果
粗提取物在各个评估时间内均能显著改善诱导的发热。分馏后，植物的氯仿和乙酸乙酯馏分的解热作用显著增强。然而，己烷和丁醇馏分的解热作用不明显。提取物对醋酸注射后引起的有害刺激有明显的抑制作用。除己烷外，其他馏分的作用也有力地支持了这一效果。
结论
简而言之，我们的研究从科学上验证了该植物作为解热剂的传统用途。
相似文献
1
Antipyretic and antinociceptive activity of Diospyros lotus L. in animals.君迁子在动物体内的解热和镇痛活性。
Asian Pac J Trop Biomed. 2014 May;4(Suppl 1):S382-6. doi: 10.12980/APJTB.4.2014C1020.
2
In vivo analgesic, antipyretic and anti-inflammatory potential of leaf extracts and fractions of Eria javanica.爪哇毛兰叶片提取物及其馏分的体内镇痛、解热和抗炎潜力
J Complement Integr Med. 2017 Mar 1;14(1). doi: 10.1515/jcim-2016-0040.
3
Antipyretic and antinociceptive potential of extract/fractions of Potentilla evestita and its isolated compound, acacetin.绵毛委陵菜提取物/馏分及其分离化合物刺槐素的解热和镇痛潜力
BMC Complement Altern Med. 2014 Nov 18;14:448. doi: 10.1186/1472-6882-14-448.
4
Antipyretic, Antinociceptive, and Anti-Inflammatory Activities from Leaf Extract in Experimental Wister Rats.实验性Wistar大鼠叶提取物的解热、镇痛和抗炎活性
Medicines (Basel). 2019 Sep 20;6(4):96. doi: 10.3390/medicines6040096.
5
Emerging CAM Ziziphus nummularia with in vivo sedative-hypnotic, antipyretic and analgesic attributes.新兴的药用植物酸枣具有体内镇静催眠、解热和镇痛作用。
3 Biotech. 2016 Jun;6(1):11. doi: 10.1007/s13205-015-0322-5. Epub 2016 Jan 5.
6
Anti-hyperalgesic activity of crude extract and 7-methyljuglone of Diospyros lotus roots.君迁子根粗提物及7-甲基胡桃醌的抗痛觉过敏活性
Nat Prod Res. 2015;29(23):2226-9. doi: 10.1080/14786419.2014.1003297. Epub 2015 Jan 21.
7
Pharmacological investigation of analgesic and antipyretic activities of methanol extract of the whole part of Aeginetia indica.镇痛和解热活性的药理学研究甲醇提取物的整个部分的 Aeginetia indica。
J Ethnopharmacol. 2021 May 10;271:113915. doi: 10.1016/j.jep.2021.113915. Epub 2021 Feb 7.
8
Antinociceptive and antipyretic activities of Pongamia pinnata leaves.水黄皮树叶的抗伤害感受和退热活性。
Phytother Res. 2003 Mar;17(3):259-64. doi: 10.1002/ptr.1126.
9
Anti-oxidant, anti-inflammatory, analgesic and antipyretic activities of grapevine leaf extract (Vitis vinifera) in mice and identification of its active constituents by LC-MS/MS analyses.葡萄叶提取物（葡萄）对小鼠的抗氧化、抗炎、镇痛和解热活性及其活性成分的LC-MS/MS分析鉴定
Biomed Pharmacother. 2016 Dec;84:1088-1098. doi: 10.1016/j.biopha.2016.10.033. Epub 2016 Oct 22.
10
GC-MS Analysis and Various In Vitro and In Vivo Pharmacological Potential of Lindl.林德勒（Lindl.）的气相色谱 - 质谱联用（GC - MS）分析及多种体外和体内药理潜力
Evid Based Complement Alternat Med. 2022 Mar 31;2022:7921408. doi: 10.1155/2022/7921408. eCollection 2022.
引用本文的文献
1
Chromosome-level genomes of seeded and seedless date plum based on third-generation DNA sequencing and Hi-C analysis.基于第三代DNA测序和Hi-C分析的有籽和无籽枣李染色体水平基因组
For Res (Fayettev). 2021 May 27;1:9. doi: 10.48130/FR-2021-0009. eCollection 2021.
2
and assessment of the anti-diabetic, analgesic, and anti-inflammatory potenstials of metal-based carboxylates derivative.以及对金属羧酸盐衍生物的抗糖尿病、镇痛和抗炎潜力的评估。
Heliyon. 2023 Aug 16;9(8):e19160. doi: 10.1016/j.heliyon.2023.e19160. eCollection 2023 Aug.
3
antioxidant, lipoxygenase inhibitory, and muscle relaxant potential of the extract and constituent isolated from (Japanese Persimmon).从（日本柿子）中提取的提取物和分离成分的抗氧化、脂氧合酶抑制及肌肉松弛潜力。
Heliyon. 2023 Feb 17;9(3):e13816. doi: 10.1016/j.heliyon.2023.e13816. eCollection 2023 Mar.
4
Drying date plum (Diospyros lotus L.) fruit: Assessing rehydration properties, antioxidant activity, and phenolic compounds.干红枣（Diospyros lotus L.）果：评估复水特性、抗氧化活性和酚类化合物。
J Food Sci. 2022 Oct;87(10):4394-4415. doi: 10.1111/1750-3841.16322. Epub 2022 Sep 16.
5
Formulation of tizanidine hydrochloride-loaded provesicular system for improved oral delivery and therapeutic activity employing a 2 full factorial design.采用 2 因素完全设计，将盐酸替扎尼定载入前体囊泡系统以改善口服传递和治疗活性。
Drug Deliv Transl Res. 2023 Feb;13(2):580-592. doi: 10.1007/s13346-022-01217-3. Epub 2022 Aug 4.
6
Biological Functions of Roxb. Against Pain, Inflammation, Fever, Diarrhea, and Thrombosis: Evidenced From , and Molecular Docking Study.罗克斯伯（Roxb.）对疼痛、炎症、发热、腹泻和血栓形成的生物学功能：来自……和分子对接研究的证据
Front Nutr. 2022 Jul 12;9:911274. doi: 10.3389/fnut.2022.911274. eCollection 2022.
7
Antibacterial, Antifungal, Antioxidant, and Docking Studies of Potential Dinaphthodiospyrols from Linn Roots.来自[植物名称] Linn 根中潜在的二萘基连苯二酚的抗菌、抗真菌、抗氧化及对接研究 。（这里你原文中“Linn Roots”前面的植物名称没给出完整哦）
ACS Omega. 2021 Feb 18;6(8):5878-5885. doi: 10.1021/acsomega.0c06297. eCollection 2021 Mar 2.
8
In vivo analgesic, anti-inflammatory, and sedative activity and a molecular docking study of dinaphthodiospyrol G isolated from Diospyros lotus.从莲属植物中分离得到的二萘并二苯并吡咯 G 的体内镇痛、抗炎和镇静活性及分子对接研究。
BMC Complement Med Ther. 2020 Jul 25;20(1):237. doi: 10.1186/s12906-020-03030-2.
9
Bergenia pacumbis from Nepal, an astonishing enzymes inhibitor.来自尼泊尔的岩白菜，一种惊人的酶抑制剂。
BMC Complement Med Ther. 2020 Jun 26;20(1):198. doi: 10.1186/s12906-020-02989-2.
10
Pharmacological evidence for the use of as a medicinal plant in the management of pain and pyrexia.作为药用植物用于疼痛和发热管理的药理学证据。
Biochem Biophys Rep. 2019 Dec 9;21:100715. doi: 10.1016/j.bbrep.2019.100715. eCollection 2020 Mar.
本文引用的文献
1
Antipyretic and anticonvulsant activity of n-hexane fraction of Viola betonicifolia.白堇菜正己烷部位的解热和抗惊厥活性。
Asian Pac J Trop Biomed. 2013 Apr;3(4):280-3. doi: 10.1016/S2221-1691(13)60063-5.
2
In vivo screening of essential oils of Skimmia laureola leaves for antinociceptive and antipyretic activity.对月桂茵芋叶精油进行体内抗伤害性感受和退热活性筛选。
Asian Pac J Trop Biomed. 2013 Mar;3(3):202-6. doi: 10.1016/S2221-1691(13)60050-7.
3
Antipyretic and anticonvulsant activity of Polygonatum verticillatum: comparison of rhizomes and aerial parts.玉竹的解热和抗惊厥活性：根茎和地上部分的比较。
Phytother Res. 2013 Mar;27(3):468-71. doi: 10.1002/ptr.4721. Epub 2012 May 21.
4
Antipyretic, analgesic and anti-inflammatory activity of Viola betonicifolia whole plant.贝氏堇菜全草的解热、镇痛和抗炎活性。
BMC Complement Altern Med. 2012 May 2;12:59. doi: 10.1186/1472-6882-12-59.
5
Translational investigation and treatment of neuropathic pain.神经病理性疼痛的转化研究与治疗。
Mol Pain. 2012 Mar 9;8:15. doi: 10.1186/1744-8069-8-15.
6
Evaluation of analgesic and anti-inflammatory activity of diospyros cordifolia extract.柿叶提取物的镇痛和抗炎活性评估。
Afr J Tradit Complement Altern Med. 2011;8(1):11-4. Epub 2010 Oct 2.
7
Pistagremic acid a new leishmanicidal triterpene isolated from Pistacia integerrima Stewart.从黄连木 Pistacia integerrima Stewart 中分离得到的新的杀利什曼原虫三萜酸 pistagremic acid。
J Enzyme Inhib Med Chem. 2012 Oct;27(5):646-8. doi: 10.3109/14756366.2011.604853. Epub 2011 Aug 18.
8
Analgesic effects and mechanisms of anti-inflammation of taraxeren-3-one from Diospyros maritima in mice.地柿中 taraxeren-3-one 的抗炎和镇痛作用及其机制在小鼠体内的研究。
J Agric Food Chem. 2011 Sep 14;59(17):9112-9. doi: 10.1021/jf201375u. Epub 2011 Aug 5.
9
Analgesic and antiinflammatory activity of kaur-16-en-19-oic acid from Annona reticulata L. bark.番荔枝树皮中的贝壳杉烯-16-烯-19-酸的镇痛和抗炎活性。
Phytother Res. 2012 Feb;26(2):273-6. doi: 10.1002/ptr.3544. Epub 2011 Jun 14.
10
Antiinflammatory, analgesic and antipyretic activities of ethanolic root extract of Croton zambesicus.赞比亚巴豆乙醇根提取物的抗炎、镇痛和解热活性
Pak J Pharm Sci. 2010 Oct;23(4):385-92.
Zotero 插件