来自二尖黄芪的环阿屯烷三萜类化合物。

Cycloartane triterpenoids from Astragalus bicuspis.

作者信息

Choudhary M Iqbal, Jan Saleem, Abbaskhan Ahmed, Musharraf Syed Ghulam, Sattar Samina A

机构信息

HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan.

出版信息

J Nat Prod. 2008 Sep;71(9):1557-60. doi: 10.1021/np800161j. Epub 2008 Sep 4.

DOI:10.1021/np800161j

PMID:18771242

Abstract

Three new cycloartane glycosides have been isolated from Astragalus bicuspis. They were identified as 6alpha-hydroxy-3-O-beta-xylopyranosyloxy-24,25,26,27-tetranor-9,19-cyclolanosta-16,23-lactone (1), 6alpha-hydroxy-23-methoxy-16beta,23(R)-epoxy-24,25,26,27-tetranor-9,19-cyclolanosta-3-O-beta-xyloside (2), and 23(R),24(S),25(R),26(S)-16beta/23,23/26,24/25-triepoxy-6alpha,26-dihydroxy-9,19-cyclolanosta-3-O-beta-xyloside (3), on the basis of their spectroscopic data. Two known cycloartane derivatives, 4 and 5, were also obtained from this plant. Compounds 2-5 were tested for leishmanicidal activity against Leishmania major promastigotes and for cytotoxicity against 3T3 cancer cells.

摘要

从二尖黄芪中分离出了三种新的环阿尔廷烷型糖苷。根据光谱数据，它们被鉴定为6α-羟基-3-O-β-吡喃木糖氧基-24,25,26,27-四降-9,19-环羊毛甾-16,23-内酯（1）、6α-羟基-23-甲氧基-16β,23（R）-环氧-24,25,26,27-四降-9,19-环羊毛甾-3-O-β-木糖苷（2）和23（R）,24（S）,25（R）,26（S）-16β/23,23/26,24/25-三环氧-6α,26-二羟基-9,19-环羊毛甾-3-O-β-木糖苷（3）。还从该植物中获得了两种已知的环阿尔廷烷衍生物4和5。测试了化合物2-5对杜氏利什曼原虫前鞭毛体的杀利什曼活性以及对3T3癌细胞的细胞毒性。