Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454-9110, USA.
Trends Neurosci. 2011 Oct;34(10):536-47. doi: 10.1016/j.tins.2011.07.006. Epub 2011 Aug 17.
According to the Hebb rule, the change in the strength of a synapse depends only on the local interaction of presynaptic and postsynaptic events. Studies at many types of synapses indicate that the early phase of long-term potentiation (LTP) has Hebbian properties. However, it is now clear that the Hebb rule does not account for late LTP; this requires an additional signal that is non-local. For novel information and motivational events such as rewards this signal at hippocampal CA1 synapses is mediated by the neuromodulator, dopamine. In this Review we discuss recent experimental findings that support the view that this 'neoHebbian' framework can account for memory behavior in a variety of learning situations.
根据赫布规则,突触强度的变化仅取决于突触前和突触后事件的局部相互作用。许多类型突触的研究表明,长时程增强(LTP)的早期阶段具有赫布特性。然而,现在很清楚,赫布规则并不能解释晚期 LTP;这需要一个额外的非局部信号。对于新的信息和激励事件,如奖励,这种海马 CA1 突触的信号是由神经调质多巴胺介导的。在这篇综述中,我们讨论了最近的实验发现,这些发现支持了这种“新赫布”框架可以解释各种学习情况下的记忆行为的观点。