Laboratory for Cognitive Neuroscience, Centre for Cognitive and Neural Systems, The University of Edinburgh, 1 George Square, Edinburgh EH8 9JZ, UK.
Nat Rev Neurosci. 2011 Jan;12(1):17-30. doi: 10.1038/nrn2963.
The synaptic tagging and capture hypothesis of protein synthesis-dependent long-term potentiation asserts that the induction of synaptic potentiation creates only the potential for a lasting change in synaptic efficacy, but not the commitment to such a change. Other neural activity, before or after induction, can also determine whether persistent change occurs. Recent findings, leading us to revise the original hypothesis, indicate that the induction of a local, synapse-specific 'tagged' state and the expression of long-term potentiation are dissociable. Additional observations suggest that there are major differences in the mechanisms of functional and structural plasticity. These advances call for a revised theory that incorporates the specific molecular and structural processes involved. Addressing the physiological relevance of previous in vitro findings, new behavioural studies have experimentally translated the hypothesis to learning and the consolidation of newly formed memories.
突触标记和捕获假说认为，蛋白合成依赖性长时程增强的诱导只产生了突触效能持久变化的可能性，但并没有决定是否发生这种变化。在诱导之前或之后的其他神经活动也可以决定是否发生持久的变化。最近的发现促使我们修改了最初的假说，表明诱导局部、突触特异性的“标记”状态和长时程增强的表达是可分离的。其他观察结果表明，功能和结构可塑性的机制有很大的不同。这些进展要求提出一个新的理论，将涉及的特定分子和结构过程纳入其中。为了解决以前体外发现的生理相关性问题，新的行为研究已经将该假说应用于学习和新形成记忆的巩固。
