Bove K E, Bhathena D, Wyatt R J, Lucas B A, Holland N H
Arch Pathol Lab Med. 1979 Apr;103(4):187-90.
Diffuse persistent glomerular immaturity and focal proximal tubular ectasia were seen in bilateral open renal biopsy specimens for an infant with fluid and salt depletion and slowly progressive renal failure. Subsequently, diffuse tubulopapillary renal adenoma subtotally replaced each kidney, thereby, necessitating renal transplantation. Origin of diffuse metanephric adenoma from persistent primitive epithelium of the proximal nephron is postulated and partly substantiated. We propose that this case of persistent proximal nephronic epithelial immaturity and diffuse metanephric adenoma is a variant of nephroblastomatosis and that in this case, a first trimester suicide attempt with aspirin may have initiated the maturation defect that preceded neoplastic transformation.
在一名患有液体和盐分缺乏以及缓慢进展性肾衰竭的婴儿的双侧开放性肾活检标本中，可见弥漫性持续性肾小球不成熟和局灶性近端肾小管扩张。随后，弥漫性肾小管乳头状肾腺瘤几乎完全取代了每个肾脏，因此需要进行肾移植。推测弥漫性后肾腺瘤起源于近端肾单位的持续原始上皮，并部分得到证实。我们提出，这种持续性近端肾单位上皮不成熟和弥漫性后肾腺瘤的病例是肾母细胞瘤病的一种变体，在这种情况下，孕早期服用阿司匹林自杀未遂可能引发了肿瘤转化之前的成熟缺陷。
