University of Pittsburgh, Department of Medicine, Division of Rheumatology and Clinical Immunology, Pittsburgh, PA 15261, USA.
Curr Opin Immunol. 2011 Oct;23(5):613-9. doi: 10.1016/j.coi.2011.07.006. Epub 2011 Aug 16.
The IL-17/IL-17 receptor family is the newest and least understood of the cytokine subclasses. Composed of ligands IL-17A-IL-17F and receptors IL-17RA-IL-17RE, these cytokines have many unique structural and functional features. Since the discovery of the 'Th17' subset in 2005, particular attention has been paid to IL-17A and IL-17F and their cognate receptors. To date, far less is known about the rest of the family. This review discusses recent advances in the field, with an emphasis on IL-17A biology.
IL-17/IL-17 受体家族是细胞因子亚类中最新和了解最少的家族。由配体 IL-17A-IL-17F 和受体 IL-17RA-IL-17RE 组成，这些细胞因子具有许多独特的结构和功能特征。自 2005 年发现 'Th17' 亚群以来，人们特别关注 IL-17A 和 IL-17F 及其同源受体。迄今为止，对该家族的其他成员了解甚少。本综述讨论了该领域的最新进展，重点介绍了 IL-17A 的生物学特性。
