1 型糖尿病的免疫干预。
Immune intervention in type 1 diabetes.
机构信息
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA.
出版信息
Semin Immunol. 2011 Jun;23(3):214-9. doi: 10.1016/j.smim.2011.07.003. Epub 2011 Aug 17.
Abstract
Type 1 diabetes (T1D) is a chronic autoimmune disease that results in the specific immune destruction of insulin producing beta cells. Currently there is no cure for T1D and treatment for the disease consists of lifelong administration of insulin. Immunotherapies aimed at preventing beta cell destruction in T1D patients with residual c-peptide or in individuals developing T1D are being evaluated. Networks of researchers such as TrialNet and the Immune Tolerance Network in the U.S. and similar networks in Europe have been established to evaluate such immunotherapies. This review focuses on immune intervention for the prevention and amelioration of human T1D with a focus on potential immune suppressive, antigen specific and environmental therapies.
摘要
1 型糖尿病（T1D）是一种慢性自身免疫性疾病，导致胰岛素产生的β细胞特异性免疫破坏。目前尚无治愈 T1D 的方法，该病的治疗包括终身胰岛素治疗。目前正在评估针对 T1D 患者中残留 C 肽或发展为 T1D 的个体的预防β细胞破坏的免疫疗法。美国的 TrialNet 和免疫耐受网络等研究网络以及欧洲的类似网络已经建立，以评估此类免疫疗法。本综述重点关注预防和改善人类 T1D 的免疫干预，重点关注潜在的免疫抑制、抗原特异性和环境疗法。
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