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大肠杆菌mutT1突变基因缺陷的特征分析

Characterization of the defect in the Escherichia coli mutT1 mutator gene.

作者信息

Bhatnagar S K, Bullions L C, Lew G, Bessman M J

机构信息

McCollum-Pratt Institute, Johns Hopkins University, Baltimore, Maryland 21218.

出版信息

J Bacteriol. 1990 May;172(5):2802-3. doi: 10.1128/jb.172.5.2802-2803.1990.

DOI:10.1128/jb.172.5.2802-2803.1990
PMID:2185234
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC208933/
Abstract

With a probe constructed from the wild-type gene, a DNA fragment containing the entire mutT1 mutator gene was isolated and cloned into pUC18. Nucleotide sequence analysis revealed that the mutator defect was most likely due to an IS1 insertion into the wild-type gene.

摘要

用由野生型基因构建的探针，分离出一个包含整个mutT1诱变基因的DNA片段，并将其克隆到pUC18中。核苷酸序列分析表明，诱变缺陷很可能是由于一个IS1插入到野生型基因中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cd9/208933/59b07cb5d7e6/jbacter00119-0617-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cd9/208933/59b07cb5d7e6/jbacter00119-0617-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cd9/208933/59b07cb5d7e6/jbacter00119-0617-a.jpg

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引用本文的文献

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本文引用的文献

1
A Factor (or Mutator Gene) Influencing Mutation Rates in Escherichia Coli.一种影响大肠杆菌突变率的因子（或诱变基因）
Proc Natl Acad Sci U S A. 1954 Nov;40(11):1064-71. doi: 10.1073/pnas.40.11.1064.
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Model for the participation of quasi-palindromic DNA sequences in frameshift mutation.准回文DNA序列参与移码突变的模型。
Proc Natl Acad Sci U S A. 1982 Jul;79(13):4128-32. doi: 10.1073/pnas.79.13.4128.
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Variant insertion element IS1 generates 8-base pair duplications of the target sequence.变异插入元件IS1会产生靶序列的8碱基对重复。
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The unusual mutagenic specificity of an E. Coli mutator gene.大肠杆菌诱变基因异常的诱变特异性。
Proc Natl Acad Sci U S A. 1966 Feb;55(2):274-81. doi: 10.1073/pnas.55.2.274.
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Frameshift mutations and the genetic code. This paper is dedicated to Professor Theodosius Dobzhansky on the occasion of his 66th birthday.移码突变与遗传密码。本文谨献给西奥多修斯·杜布赞斯基教授，以庆祝他66岁生日。
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Studies on the mutator gene, mutT of Escherichia coli. Molecular cloning of the gene, purification of the gene product, and identification of a novel nucleoside triphosphatase.大肠杆菌诱变基因mutT的研究。该基因的分子克隆、基因产物的纯化以及一种新型核苷三磷酸酶的鉴定。
J Biol Chem. 1988 Jun 25;263(18):8953-7.
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Molecular cloning and nucleotide sequence of the mutT mutator of Escherichia coli that causes A:T to C:G transversion.导致A:T到C:G颠换的大肠杆菌mutT诱变基因的分子克隆与核苷酸序列
Mol Gen Genet. 1987 Jan;206(1):9-16. doi: 10.1007/BF00326530.
9
A specific role of MutT protein: to prevent dG.dA mispairing in DNA replication.MutT蛋白的一个特定作用：防止DNA复制过程中dG.dA错配。
Proc Natl Acad Sci U S A. 1989 Jun;86(11):3949-52. doi: 10.1073/pnas.86.11.3949.
10
Study of a suppressor of mutT in Escherichia coli.大肠杆菌中mutT抑制因子的研究。
Mol Gen Genet. 1979 Mar 20;171(2):215-8. doi: 10.1007/BF00270007.