噬菌体T4的DNA腺嘌呤甲基转移酶（dam+）基因可逆转大肠杆菌dam突变体的突变表型。
The DNA adenine methyltransferase (dam+) gene of bacteriophage T4 reverses the mutator phenotype of an Escherichia coli dam mutant.
作者信息
Hall R M
机构信息
Laboratory for Molecular Biology, CSIRO Division of Biotechnology, North Ryde, NSW, Australia.
出版信息
J Bacteriol. 1990 May;172(5):2812-3. doi: 10.1128/jb.172.5.2812-2813.1990.
Abstract
The mutator phenotype of Escherichia coli dam mutants was found to be reversed by introduction of the bacteriophage T4 gene for DNA adenine methyltransferase. This precludes a direct role for the E. coli DNA adenine methyltransferase in mismatch repair, in addition to its role in strand discrimination, as suggested by earlier studies (S. L. Schlagman, S. Hattman, and M. G. Marinus, J. Bacteriol. 165:896-900, 1986).
摘要
通过引入噬菌体T4的DNA腺嘌呤甲基转移酶基因，发现大肠杆菌dam突变体的突变体表型被逆转。这排除了大肠杆菌DNA腺嘌呤甲基转移酶除了早期研究（S. L. Schlagman、S. Hattman和M. G. Marinus，《细菌学杂志》165:896 - 900，1986）所表明的在链区分中的作用外，在错配修复中起直接作用的可能性。
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The DNA adenine methyltransferase (dam+) gene of bacteriophage T4 reverses the mutator phenotype of an Escherichia coli dam mutant.噬菌体T4的DNA腺嘌呤甲基转移酶（dam+）基因可逆转大肠杆菌dam突变体的突变表型。
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