McGraw B R, Marinus M G
Mol Gen Genet. 1980;178(2):309-15. doi: 10.1007/BF00270477.
Bacteria mutant in the dam (DNA adenine methylation) gene and in either recA or recB or recC genes are inviable (Virm- phenotype). From crosses between dam-3 bacteria and recA1 or recB21 recC22 strains, Vrm+ recombinants were recovered. Among these recombinants, Dam+ revertants were present which did not show the phenotypes normally associated with dam-3 bacteria. Three classes of indirectly suppressed strains (dam-3 genotype) were also recovered which showed alterations in the secondary phenotypes normally associated with dam-3 bacteria. These strains contained a second unlinked mutation in either mutL or mutS or sin. In addition, mutation in either sbcA or sbcB supresses the Vrm- phenotype of dam-3 recB21 recC22 strains.
在dam（DNA腺嘌呤甲基化）基因以及recA或recB或recC基因中发生突变的细菌是无法存活的（Virm-表型）。从dam-3细菌与recA1或recB21 recC22菌株之间的杂交中，获得了Vrm+重组体。在这些重组体中，存在Dam+回复体，其未表现出通常与dam-3细菌相关的表型。还获得了三类间接抑制菌株（dam-3基因型），它们在通常与dam-3细菌相关的二级表型上表现出改变。这些菌株在mutL或mutS或sin中含有第二个不连锁的突变。此外，sbcA或sbcB中的突变抑制了dam-3 recB21 recC22菌株的Vrm-表型。
