Romero-Cordero Sonia, Kirwan Richard, Noguera-Julian Antoni, Cardellach Francesc, Fortuny Clàudia, Morén Constanza
Faculty of Medicine, Pompeu Fabra University and Universitat Autònoma de Barcelona, 08002 Barcelona, Spain.
School of Biological and Environmental Sciences, Liverpool John Moores University, Liverpool L2 2QP, UK.
Int J Mol Sci. 2021 Mar 23;22(6):3272. doi: 10.3390/ijms22063272.
Infectious diseases occur worldwide with great frequency in both adults and children. Both infections and their treatments trigger mitochondrial interactions at multiple levels: (i) incorporation of damaged or mutated proteins to the complexes of the electron transport chain, (ii) mitochondrial genome (depletion, deletions, and point mutations) and mitochondrial dynamics (fusion and fission), (iii) membrane potential, (iv) apoptotic regulation, (v) generation of reactive oxygen species, among others. Such alterations may result in serious adverse clinical events with great impact on children's quality of life, even resulting in death. As such, bacterial agents are frequently associated with loss of mitochondrial membrane potential and cytochrome c release, ultimately leading to mitochondrial apoptosis by activation of caspases-3 and -9. Using Rayyan QCRI software for systematic reviews, we explore the association between mitochondrial alterations and pediatric infections including (i) bacterial: , and (ii) parasitic: . We analyze how these pediatric infections and their treatments may lead to mitochondrial deterioration in this especially vulnerable population, with the intention of improving both the understanding of these diseases and their management in clinical practice.
传染病在全球范围内的成人和儿童中都极为常见。感染及其治疗都会在多个层面引发线粒体相互作用：（i）受损或突变的蛋白质掺入电子传递链复合物中；（ii）线粒体基因组（耗竭、缺失和点突变）以及线粒体动力学（融合和裂变）；（iii）膜电位；（iv）凋亡调控；（v）活性氧的产生等等。此类改变可能导致严重的不良临床事件，对儿童生活质量产生重大影响，甚至导致死亡。因此，细菌病原体常与线粒体膜电位丧失和细胞色素c释放相关，最终通过激活半胱天冬酶-3和-9导致线粒体凋亡。我们使用Rayyan QCRI软件进行系统评价，探讨线粒体改变与儿科感染之间的关联，其中包括（i）细菌感染：[具体细菌名称未给出]、[具体细菌名称未给出]和[具体细菌名称未给出]，以及（ii）寄生虫感染：[具体寄生虫名称未给出]。我们分析这些儿科感染及其治疗如何导致这个特别脆弱群体的线粒体恶化，目的是增进对这些疾病的了解以及改善临床实践中的疾病管理。
