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Bumetanide, an NKCC1 antagonist, does not prevent formation of epileptogenic focus but blocks epileptic focus seizures in immature rat hippocampus.布美他尼，一种NKCC1拮抗剂，不能阻止致痫灶的形成，但能阻断未成熟大鼠海马体中癫痫灶的发作。
J Neurophysiol. 2009 Jun;101(6):2878-88. doi: 10.1152/jn.90761.2008. Epub 2009 Mar 18.
2
Model-specific effects of bumetanide on epileptiform activity in the in-vitro intact hippocampus of the newborn mouse.布美他尼对新生小鼠体外完整海马体癫痫样活动的模型特异性影响。
Neuropharmacology. 2007 Sep;53(4):524-33. doi: 10.1016/j.neuropharm.2007.06.015. Epub 2007 Jun 30.
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Effects of antiepileptic drugs on refractory seizures in the intact immature corticohippocampal formation in vitro.
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In vitro formation of a secondary epileptogenic mirror focus by interhippocampal propagation of seizures.通过海马间癫痫传播在体外形成继发性致痫性镜像灶。
Nat Neurosci. 2003 Oct;6(10):1079-85. doi: 10.1038/nn1125. Epub 2003 Sep 21.
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Excitatory actions of gaba during development: the nature of the nurture.γ-氨基丁酸在发育过程中的兴奋性作用：后天培养的本质
Nat Rev Neurosci. 2002 Sep;3(9):728-39. doi: 10.1038/nrn920.
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The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation.钾离子/氯离子共转运体KCC2在神经元成熟过程中使γ-氨基丁酸（GABA）产生超极化作用。
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Rapid seizure-induced reduction of benzodiazepine and Zn2+ sensitivity of hippocampal dentate granule cell GABAA receptors.癫痫发作迅速导致海马齿状颗粒细胞GABAA受体对苯二氮䓬和锌离子的敏感性降低。
J Neurosci. 1997 Oct 1;17(19):7532-40. doi: 10.1523/JNEUROSCI.17-19-07532.1997.
8
Synaptic modifications accompanying epileptogenesis in vitro: long-term depression of GABA-mediated inhibition.体外癫痫发生过程中的突触修饰：GABA 介导的抑制性突触后电位的长时程抑制
Brain Res. 1993 Nov 12;627(2):330-40. doi: 10.1016/0006-8993(93)90338-n.
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Age-dependent effects of gamma-aminobutyric acid agents on flurothyl seizures.
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Increased seizure susceptibility of the immature brain.
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Chloride's Exciting Role in Neonatal Seizures Suggests Novel Therapeutic Approach.

作者信息

Merlin Lisa R

出版信息

Epilepsy Curr. 2011 May;11(3):92-3. doi: 10.5698/1535-7511-11.3.92.

DOI:10.5698/1535-7511-11.3.92
PMID:21852872
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3117493/
Abstract
摘要