Department of Radiology and the Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, 86 Asanbyeongwon-gil, Songpa-gu, Seoul, Korea.
Korean J Radiol. 2011 Jul-Aug;12(4):456-62. doi: 10.3348/kjr.2011.12.4.456. Epub 2011 Jul 22.
We wanted to evaluate the diagnostic value of serum CA-125 concentration, when used in combination with the preoperative contrast-enhanced CT results, to differentiate borderline ovarian tumors (BOTs) from stage I malignant epithelial ovarian tumors (MEOTs).
Ninety-eight masses (46 BOTs and 52 stage I MEOTs) from 87 consecutive patients (49 with BOTs and 38 with stage I MEOTs) who had undergone preoperative contrast-enhanced computed tomography (CT) and surgical staging were evaluated retrospectively and independently by two radiologists. The preoperative serum CA-125 concentration was measured in all patients. The utility of analyzing serum CA-125 concentration in combination with the CT results was evaluated by receiver operating characteristic (ROC) curve analysis.
An irregular tumor surface and lymphadenopathy were predictive of a MEOT. ROC analysis showed that the combination of CT data and the serum CA-125 level resulted in a higher diagnostic performance than did using the CT alone for differentiating BOTs from MEOTs. The areas under the curves (AUCs) without and with the use of the serum CA-125 level data were 0.67 (95% confidence interval [CI]: 0.57-0.77) and 0.78 (95% CI: 0.68-0.85), respectively, for reader 1 (p = 0.029) and 0.71 (95% CI: 0.61-0.80) and 0.81 (95% CI: 0.72-0.89), respectively, for reader 2 (p = 0.009).
The serum CA-125 concentration is of additional diagnostic value when used in conjunction with the CT imaging results for differentiating BOTs from MEOTs.
我们旨在评估血清 CA-125 浓度与术前增强 CT 结果联合应用时的诊断价值，以区分交界性卵巢肿瘤（BOT）和 I 期上皮性卵巢恶性肿瘤（MEOT）。
回顾性分析 87 例连续患者（49 例 BOT 和 38 例 I 期 MEOT）98 个肿块（46 个 BOT 和 52 个 I 期 MEOT）的术前增强 CT 及手术分期资料，由 2 名放射科医生独立进行评估。所有患者均检测术前血清 CA-125 浓度。采用受试者工作特征（ROC）曲线分析评估联合分析血清 CA-125 浓度与 CT 结果的效用。
不规则肿瘤表面和淋巴结肿大是 MEOT 的预测因素。ROC 分析表明，与仅使用 CT 相比，CT 数据与血清 CA-125 水平相结合可提高诊断性能，从而有助于区分 BOT 和 MEOT。两位读者评估时，曲线下面积（AUC）分别为 0.67（95%置信区间[CI]：0.57-0.77）和 0.78（95% CI：0.68-0.85）（无血清 CA-125 水平数据）和 0.71（95% CI：0.61-0.80）和 0.81（95% CI：0.72-0.89）（有血清 CA-125 水平数据），差异有统计学意义（p=0.029 和 p=0.009）。
血清 CA-125 浓度与 CT 成像结果联合应用时，对区分 BOT 和 MEOT 具有附加诊断价值。
