Wahlländer A, Mohr S, Paumgartner G
Department of Medicine II, Klinikum Grosshadern, University of Munich, Federal Republic of Germany.
J Hepatol. 1990 Mar;10(2):129-37. doi: 10.1016/0168-8278(90)90041-o.
Hepatic microsomal function was assessed by a caffeine clearance test at night and during the day using saliva and serum samples obtained simultaneously. In 26 patients with cirrhosis, 21 patients with noncirrhotic liver disease and 15 control subjects caffeine elimination correlated well during the day and at night (r = 0.915 for serum and 0.917 for saliva). The correlation coefficients for caffeine clearance in saliva and serum were 0.940 during the day and 0.963 overnight. In the cirrhotic patients, clearance differed significantly from noncirrhotic liver disease and controls in saliva samples overnight: 0.51 +/- 0.45 ml/min per kg versus 0.91 +/- 0.44 and 1.41 +/- 0.56, respectively. Comparable results were obtained for serum clearance overnight and clearances during the day. Serum and saliva clearances at night correlated well with the aminopyrine breath test (rs = 0.884 and 0.907, respectively). Overnight caffeine clearance in saliva might be a simple useful method for assessing progression and prognosis of liver disease.
通过夜间和白天的咖啡因清除试验评估肝微粒体功能，同时采集唾液和血清样本。在26例肝硬化患者、21例非肝硬化肝病患者和15例对照受试者中，白天和夜间的咖啡因消除情况相关性良好（血清的r = 0.915，唾液的r = 0.917）。白天唾液和血清中咖啡因清除率的相关系数为0.940，夜间为0.963。在肝硬化患者中，夜间唾液样本的清除率与非肝硬化肝病患者和对照相比有显著差异：分别为0.51±0.45 ml/min per kg、0.91±0.44和1.41±0.56。夜间血清清除率和白天清除率也得到了类似结果。夜间血清和唾液清除率与氨基比林呼气试验相关性良好（rs分别为0.884和0.907）。夜间唾液中的咖啡因清除率可能是评估肝病进展和预后的一种简单有用的方法。
