Endocrine Research Center (Firouzgar), Institute of Endocrinology and Metabolism (Hemmat Campus), Tehran University of Medical Sciences, Tehran, Iran.
Lasers Med Sci. 2011 Nov;26(6):831-5. doi: 10.1007/s10103-011-0977-z. Epub 2011 Aug 19.
Low-intensity laser therapy (LILT) has been considered as a treatment modality in diabetic distal symmetric polyneuropathy (DSP). The aim of this study is to determine the effectiveness of LILT on DSP. We examined 107 subjects with type 2 diabetes for detection of DSP using the Michigan Neuropathy Screening Instrument (MNSI). Seventeen subjects were eligible to be enrolled in the study. Nerve conduction studies (NCS) were performed in all eligible subjects as an objective method to confirm neuropathy. The participants received LILT three times a week for ten sessions. NCSs were reevaluated after completion of the treatment. The absolute changes in NCS parameters were considered to establish the effectiveness of the treatment. Baseline demographics were similar in all participants. The mean differences of NCV parameters were considered for comparison. At the end of the study, the subjects showed a significant increase in neural potential amplitudes (p < 0.05). This study clearly demonstrated a significant positive effect of LILT on improvement of nerve conduction velocity on diabetic distal symmetric polyneuropathy (DSP). This finding supports the therapeutic potential of LILT in DSP.
低强度激光疗法（LILT）已被认为是治疗糖尿病远端对称性多发性神经病（DSP）的一种方法。本研究旨在确定 LILT 对 DSP 的治疗效果。我们使用密歇根神经病变筛查工具（MNSI）对 107 例 2 型糖尿病患者进行了 DSP 的检测。17 名受试者符合入组研究标准。对所有符合条件的受试者进行神经传导研究（NCS）作为客观方法以确认神经病。参与者每周接受 LILT 治疗 3 次，共 10 个疗程。治疗完成后重新评估 NCS。将 NCS 参数的绝对变化作为治疗效果的评估依据。所有参与者的基线人口统计学特征相似。比较时考虑 NCV 参数的平均差异。研究结束时，受试者的神经电位幅度明显增加（p < 0.05）。本研究清楚地表明，LILT 对改善糖尿病远端对称性多发性神经病（DSP）的神经传导速度具有显著的积极作用。这一发现支持 LILT 在 DSP 中的治疗潜力。
