Department of Urology, College of Medicine, Dong-A University, Busan 602-714, South Korea.
Immunopharmacol Immunotoxicol. 2012 Apr;34(2):244-6. doi: 10.3109/08923973.2011.599034. Epub 2011 Aug 19.
The study evaluated the anticomplement activity from isolated compounds from Artemisia rubripes Nakai from South Korea on the classical pathway. In the previous works, Artemisia rubripes chloroform extracts showed inhibitory activity against complement system. The chromatographic separation of a chloroform chloride extract of Artemisia rubripes led to the isolation of three compounds. Their structures were characterized to be scopoletin (1), 11,(13)-triene-6,12-olide (2), and 1β,6α-dihydroxy-4(15)-eudesmene (3) by spectroscopic data. This is the first report of anticomplement activity of isolated compounds from Artemisia rubripes.
该研究评估了来自韩国艾草的分离化合物对经典途径的抗补体活性。在之前的工作中，艾草的氯仿提取物显示出对补体系统的抑制活性。艾草的氯仿提取物的色谱分离导致了三种化合物的分离。通过光谱数据将它们的结构表征为东莨菪内酯（1），11，（13）-三烯-6,12-内酯（2）和 1β，6α-二羟基-4（15）-桉叶烷（3）。这是首次报道从艾草中分离出的化合物具有抗补体活性。
