Department of Neuroscience, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Prog Brain Res. 2011;193:221-32. doi: 10.1016/B978-0-444-53839-0.00014-4.
In a variety of mammalian species, sleep amounts are highest during developmental periods of rapid brain development and synaptic plasticity than at any other time in life [Frank, M. G. & Heller, H. C. (1997a). Development of REM and slow wave sleep in the rat. American Journal of Physiology, 272, R1792-R1799; Jouvet-Mounier, D., Astic, L., & Lacote, D. (1970). Ontogenesis of the states of sleep in rat, cat and guinea pig during the first postnatal month. Developmental Psychobiology, 2, 216-239; Roffwarg, H. P., Muzio, J. N., & Dement, W. C. (1966). Ontogenetic development of the human sleep-dream cycle. Science, 604-619]. Many of the mechanisms governing developmental plasticity also mediate plasticity in the adult brain. Therefore, studying the role of sleep in developmental plasticity may provide insights more generally into sleep function across the lifespan. In this chapter, I review the evidence that supports a critical role for sleep in developmental brain plasticity. I begin with an overview of past studies that support a role for sleep in general brain maturation. This is followed by more recent findings in the developing visual cortex that more specifically address a possible role for sleep in cortical plasticity.
在许多哺乳动物物种中，睡眠量在大脑快速发育和突触可塑性的发育时期最高，而在生命的其他任何时候都较低[Frank, M. G. & Heller, H. C. (1997a)。老鼠的 REM 和慢波睡眠的发展。美国生理学杂志，272，R1792-R1799；Jouvet-Mounier，D.，Astic，L.，& Lacote，D. (1970)。大鼠、猫和豚鼠在出生后第一个月的睡眠状态的发生。发展心理生物学，2，216-239；Roffwarg, H. P.，Muzio, J. N.，& Dement, W. C. (1966)。人类睡眠-梦周期的发育发展。科学，604-619]。许多调节发育可塑性的机制也介导了成年大脑的可塑性。因此，研究睡眠在发育可塑性中的作用可能为整个生命周期的睡眠功能提供更广泛的见解。在这一章中，我回顾了支持睡眠对发育中大脑可塑性具有关键作用的证据。我首先概述了支持睡眠对一般大脑成熟具有作用的过去研究。接下来是关于发育中的视觉皮层中更具体地探讨睡眠对皮质可塑性的可能作用的最新发现。
