DNA 复制：哺乳动物 Treslin-TopBP1 相互作用类似于酵母 Sld3-Dpb11。
DNA replication: mammalian Treslin-TopBP1 interaction mirrors yeast Sld3-Dpb11.
机构信息
Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22908, USA.
出版信息
Curr Biol. 2011 Aug 23;21(16):R638-40. doi: 10.1016/j.cub.2011.07.004.
Abstract
There are many parallels between DNA replication in yeast and humans. Now, two recent studies extend this relationship by dissecting key conserved interactions necessary for initiation of the replisome.
摘要
酵母和人类的 DNA 复制之间存在许多相似之处。如今，两项最新研究通过剖析复制体起始所必需的关键保守相互作用，扩展了这种关系。
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本文引用的文献
1
Regulation of DNA replication through Sld3-Dpb11 interaction is conserved from yeast to humans.通过 Sld3-Dpb11 相互作用调控 DNA 复制在从酵母到人之间是保守的。
Curr Biol. 2011 Jul 12;21(13):1152-7. doi: 10.1016/j.cub.2011.05.057. Epub 2011 Jun 23.
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Direct regulation of Treslin by cyclin-dependent kinase is essential for the onset of DNA replication.周期蛋白依赖性激酶对 Treslin 的直接调控对于 DNA 复制的起始是必不可少的。
J Cell Biol. 2011 Jun 13;193(6):995-1007. doi: 10.1083/jcb.201102003. Epub 2011 Jun 6.
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Damage-induced phosphorylation of Sld3 is important to block late origin firing.损伤诱导的 Sld3 磷酸化对于阻止晚期起始原点的激活很重要。
Nature. 2010 Sep 23;467(7314):479-83. doi: 10.1038/nature09377.
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Checkpoint-dependent inhibition of DNA replication initiation by Sld3 and Dbf4 phosphorylation.Sld3 和 Dbf4 磷酸化依赖检验点抑制 DNA 复制起始。
Nature. 2010 Sep 23;467(7314):474-8. doi: 10.1038/nature09373. Epub 2010 Sep 12.
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Cyclin-dependent kinase-dependent initiation of chromosomal DNA replication.周期蛋白依赖性激酶依赖性的染色体 DNA 复制起始。
Curr Opin Cell Biol. 2010 Dec;22(6):766-71. doi: 10.1016/j.ceb.2010.07.015. Epub 2010 Aug 20.
6
Homology explains the functional similarities of Treslin/Ticrr and Sld3.同源性解释了Treslin/Ticrr和Sld3的功能相似性。
Curr Biol. 2010 Jun 22;20(12):R509-10. doi: 10.1016/j.cub.2010.05.021.
7
How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?Cdc7 和细胞周期蛋白依赖性激酶如何引发真核细胞染色体复制的起始？
Genes Dev. 2010 Jun 15;24(12):1208-19. doi: 10.1101/gad.1933010.
8
GEMC1 is a TopBP1-interacting protein required for chromosomal DNA replication.GEMC1 是一个与 TopBP1 相互作用的蛋白，对于染色体 DNA 复制是必需的。
Nat Cell Biol. 2010 May;12(5):484-91. doi: 10.1038/ncb2050. Epub 2010 Apr 11.
9
CDK-dependent complex formation between replication proteins Dpb11, Sld2, Pol (epsilon}, and GINS in budding yeast.在芽殖酵母中，复制蛋白 Dpb11、Sld2、Pol (epsilon) 和 GINS 之间的 CDK 依赖性复合物形成。
Genes Dev. 2010 Mar 15;24(6):602-12. doi: 10.1101/gad.1883410.
10
Activation of the MCM2-7 helicase by association with Cdc45 and GINS proteins.MCM2-7 解旋酶通过与 Cdc45 和 GINS 蛋白的结合被激活。
Mol Cell. 2010 Jan 29;37(2):247-58. doi: 10.1016/j.molcel.2009.12.030.
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