Emergency Department, Cliniques Universitaires St-Luc, Université Catholique de Louvain, 1200, Belgium.
Am J Emerg Med. 2012 Sep;30(7):1325.e1-3. doi: 10.1016/j.ajem.2011.06.031. Epub 2011 Aug 19.
Mondor disease is a form of superficial thrombophlebitis affecting the subcutaneous veins, specifically of the anterolateral thoracoabdominal wall. Clinical presentation is commonly a subcutaneous, tender, painful cordlike induration, usually founded in the breast or axilla. It affects typically middle-aged women. A 36-year-old patient was admitted to the emergency department to a chest discomfort and to discovery of a palpable, nonerythematous, and painful cordlike structure running from the inferior pole of her left breast to the left iliac pit. She had no history of trauma, injury, or intensive physical activity. Ultrasonography confirmed thrombosis of the thoracoepigastric vein. A thrombophilic workup performed 2 years ago was normal. The patient was treated by enoxaparin 1 mg/kg per day for 30 days. Evolution was favorable. The etiology of Mondor disease remains unclear. Predisposing factors are mainly trauma, excessive physical activity, surgery, infections. Ultrasonography is used to confirm the diagnosis. Coagulation tests should be performed to exclude hypercoagulability condition. In the past, symptomatic approach with anti-inflammatory drugs was proposed. Recent guidelines suggest prophylactic or intermediate doses of low-molecular-weight heparin for at least 4 weeks. Although uncommon, Mondor disease has to be recognized to avoid useless diagnosis testing and to deliver a specific treatment.
芒多氏病是一种影响皮下静脉的浅表血栓性静脉炎,特别是前外侧胸腹壁的皮下静脉。临床表现通常为皮下、触痛、疼痛的条索状硬结,通常位于乳房或腋窝。它通常影响中年妇女。一名 36 岁的患者因胸痛和发现从她左乳房下极延伸至左髂窝的可触及的、非红斑的、疼痛的条索状结构而被收入急诊科。她没有外伤、损伤或剧烈体力活动的病史。超声检查证实胸腹壁静脉血栓形成。两年前进行的血栓形成倾向检查正常。患者接受了依诺肝素 1 毫克/公斤/天治疗 30 天。病情好转。芒多氏病的病因仍不清楚。主要的诱发因素是创伤、过度体力活动、手术、感染。超声检查用于确认诊断。应进行凝血试验以排除高凝状态。过去,建议采用抗炎药物进行对症治疗。最近的指南建议使用预防剂量或中等剂量的低分子肝素至少 4 周。尽管不常见,但芒多氏病必须得到识别,以避免不必要的诊断测试并提供特定的治疗。