围产期炎症与肺损伤。
Perinatal inflammation and lung injury.
机构信息
Department of Pediatrics, University of Maryland School of Medicine, 29 S. Greene St., Rm GS110, Baltimore, MD 21201, USA.
出版信息
Semin Fetal Neonatal Med. 2012 Feb;17(1):30-5. doi: 10.1016/j.siny.2011.08.002. Epub 2011 Sep 8.
Abstract
Bronchopulmonary dysplasia (BPD) remains the major morbidity of extreme preterm birth. The incidence of BPD has remained stable despite recent efforts to reduce postnatal exposures to volutrauma and hyperoxia. This review will focus on recent clinical and experimental insights that provide support for the concept that the 'new BPD' is the result of inflammation-mediated injury and altered lung development during a window of vulnerability in genetically susceptible infants that is modified by maternal and postnatal exposures.
摘要
支气管肺发育不良（BPD）仍然是极早产儿的主要发病机制。尽管最近努力减少了对气压伤和高氧的暴露，但 BPD 的发病率仍然保持稳定。这篇综述将重点介绍最近的临床和实验研究进展，这些进展为以下观点提供了支持：“新型 BPD”是在易感婴儿的易损窗口期间，炎症介导的损伤和肺发育改变的结果，这种改变受母体和产后暴露的影响。
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