Dirix L Y, Van Oosterom A T
Department of Oncology, Antwerp University Hospital, Belgium.
Semin Oncol. 1990 Apr;17(2 Suppl 4):50-7.
Ifosfamide is an analogue of cyclophosphamide that has been extensively investigated in sarcomas. Like doxorubicin and dacarbazine, it belongs to the class of drugs active against advanced soft tissue sarcomas; its optimal use in combination regimens has not been identified. In the treatment of osteosarcoma and Ewing's sarcoma, ifosfamide has been identified as an effective drug. Nonetheless, in these diseases, too, its optimal place in combination therapy has not yet been determined.
异环磷酰胺是环磷酰胺的类似物，已在肉瘤中进行了广泛研究。与阿霉素和达卡巴嗪一样，它属于对晚期软组织肉瘤有效的药物类别；其在联合治疗方案中的最佳应用尚未确定。在骨肉瘤和尤因肉瘤的治疗中，异环磷酰胺已被确定为一种有效药物。尽管如此，在这些疾病中，其在联合治疗中的最佳地位也尚未确定。
