[异环磷酰胺用于儿童恶性肿瘤——以色列北部肿瘤中心的经验]
[Ifosfamide in pediatric malignancy--experiences in the Northern Israel Oncology Center].
作者信息
Roguin A, Ben Arush M W, Higasi A, Kuten A
机构信息
Pediatric Oncology Unit, Rambam Medical Center, Technion-Israel Institute of Technology, Haifa.
出版信息
Harefuah. 1996 Apr 15;130(8):511-4, 584.
The records of 46 children treated with ifosfamide between 1987-1994 were analyzed. 24 received the drug as first-line chemotherapy in combination with vincristine and etoposide or with adriamycin, vincristine and cyclophosphamide. Complete remission was achieved in 8/10 children with soft tissue sarcoma, 7/8 with Ewing's sarcoma, 2/2 with ovarian carcinoma and 2/2 with clear cell sarcoma of the kidney. 22 children in whom first-line chemotherapy failed were then treated with ifosfamide and etoposide. Complete remission was achieved in 7/10 children with osteosarcoma, 1/2 with Wilms' tumor and 1/3 with neuroblastoma.
对1987年至1994年间接受异环磷酰胺治疗的46名儿童的记录进行了分析。24名儿童将该药物作为一线化疗药物，与长春新碱和依托泊苷联合使用，或与阿霉素、长春新碱和环磷酰胺联合使用。10例软组织肉瘤患儿中有8例完全缓解，8例尤因肉瘤患儿中有7例完全缓解，2例卵巢癌患儿中有2例完全缓解，2例肾透明细胞肉瘤患儿中有2例完全缓解。22例一线化疗失败的儿童随后接受了异环磷酰胺和依托泊苷治疗。10例骨肉瘤患儿中有7例完全缓解，2例肾母细胞瘤患儿中有1例完全缓解，3例神经母细胞瘤患儿中有1例完全缓解。
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