Mulvenna Jason, Yonglitthipagon Ponlapat, Sripa Banchob, Brindley Paul J, Loukas Alex, Bethony Jeffrey M
Queensland Tropical Health Alliance, James Cook University, Cairns, QLD 4878, Australia.
Parasitol Int. 2012 Mar;61(1):173-7. doi: 10.1016/j.parint.2011.06.005. Epub 2011 Aug 9.
Cholangiocarcinoma (CCA)--bile duct cancer--is associated with late presentation, poses challenges for diagnosis, and has high mortality. These features t highlight the desperate need for biomarkers than can be measured early and in accessible body fluids such as plasma of people at risk for developing this lethal cancer. In this manuscript, we address previous limitations in the discovery stage of biomarker(s) for CCA and indicate how new generation of "omics" technologies could be used for biomarker discovery in Thailand. A key factor in the success of this biomarker program for CCA is the combination of cutting edge technology with strategic sample acquisition by a biorepositories.
胆管癌（CCA）——胆管癌——与晚期发病相关，诊断面临挑战，且死亡率高。这些特征凸显了对生物标志物的迫切需求，这些生物标志物能够在早期且可从诸如处于患这种致命癌症风险的人群的血浆等易获取的体液中进行测量。在本手稿中，我们解决了此前在CCA生物标志物发现阶段存在的局限性，并指出新一代“组学”技术如何可用于泰国的生物标志物发现。该CCA生物标志物计划成功的一个关键因素是前沿技术与生物样本库进行战略样本采集的结合。
