Tropical Disease Research Laboratory, Department of Pathology, Khon Kaen University, Khon Kaen 40002, Thailand.
Acta Trop. 2011 Sep;120 Suppl 1(Suppl 1):S158-68. doi: 10.1016/j.actatropica.2010.07.006. Epub 2010 Jul 23.
Liver fluke infection caused by Opisthorchis viverrini is a major public health problem in Thailand and the Lao People's Democratic Republic (Lao PDR; Laos). Currently, more than 600 million people are at risk of infection with these fish-borne trematodes and/or their close relatives. Opisthorchiasis has been studied extensively in Thailand, where about 8 million people are infected with the liver fluke. Here we review the pathogenesis, control and re-emergence of O. viverrini infection, in particular in Thailand and, to a lesser extent in Lao PDR given the contiguous geographical range of O. viverrini through these two regions. We also review the association of O. viverrini infection and cholangiocarcinoma, bile duct cancer, and highlight new findings on pathogenesis of liver fluke-induced cholangiocarcinogenesis. Last, we comment on national control strategies in Thailand for the control of O. viverrini infection aimed at reduction in the prevalence of O. viverrini-associated liver cancer in the longer term.
肝片形吸虫感染由华支睾吸虫引起，是泰国和老挝人民民主共和国（老挝；老挝）的一个主要公共卫生问题。目前，超过 6 亿人面临感染这些鱼类吸虫及其近亲的风险。在泰国，对华支睾吸虫进行了广泛的研究，大约有 800 万人感染了这种肝吸虫。在这里，我们回顾了华支睾吸虫感染的发病机制、控制和再现，特别是在泰国，在老挝人民民主共和国也有一定程度的回顾，因为华支睾吸虫在这两个地区的地理范围是相连的。我们还回顾了华支睾吸虫感染与胆管癌、胆管癌的关系，并强调了肝吸虫诱导胆管癌发生的发病机制的新发现。最后，我们评论了泰国为控制华支睾吸虫感染而制定的国家控制策略，以期在长期内降低与华支睾吸虫相关的肝癌的流行率。
