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本文引用的文献

1
Cholangiocarcinoma and its management.胆管癌及其治疗
Gut. 2007 Dec;56(12):1755-6. doi: 10.1136/gut.2007.138859.
2
Risk factors for intrahepatic and extrahepatic cholangiocarcinoma in the United States: a population-based case-control study.美国肝内和肝外胆管癌的危险因素：一项基于人群的病例对照研究。
Clin Gastroenterol Hepatol. 2007 Oct;5(10):1221-8. doi: 10.1016/j.cgh.2007.05.020. Epub 2007 Aug 6.
3
Liver fluke induces cholangiocarcinoma.肝吸虫诱发胆管癌。
PLoS Med. 2007 Jul;4(7):e201. doi: 10.1371/journal.pmed.0040201.
4
Incidence rates of intra- and extrahepatic cholangiocarcinomas in Denmark from 1978 through 2002.1978年至2002年丹麦肝内和肝外胆管癌的发病率
J Natl Cancer Inst. 2007 Jun 6;99(11):895-7. doi: 10.1093/jnci/djk201.
5
Cholangiocarcinoma: emerging approaches to a challenging cancer.胆管癌：应对这一具有挑战性癌症的新方法
Curr Opin Gastroenterol. 2007 May;23(3):317-23. doi: 10.1097/MOG.0b013e3280495451.
6
Risk factors for intrahepatic and extrahepatic cholangiocarcinoma: a hospital-based case-control study.肝内和肝外胆管癌的危险因素：一项基于医院的病例对照研究。
Am J Gastroenterol. 2007 May;102(5):1016-21. doi: 10.1111/j.1572-0241.2007.01104.x. Epub 2007 Feb 23.
7
Cancer statistics, 2007.2007年癌症统计数据。
CA Cancer J Clin. 2007 Jan-Feb;57(1):43-66. doi: 10.3322/canjclin.57.1.43.
8
Risk factors for intrahepatic cholangiocarcinoma in a low-risk population: a nationwide case-control study.低风险人群肝内胆管癌的危险因素：一项全国性病例对照研究。
Int J Cancer. 2007 Feb 1;120(3):638-41. doi: 10.1002/ijc.22283.
9
Ultrasound screening for Opisthorchis viverrini-associated cholangiocarcinomas: experience in an endemic area.华支睾吸虫相关胆管癌的超声筛查：流行地区的经验
Asian Pac J Cancer Prev. 2006 Jul-Sep;7(3):431-3.
10
Racial and ethnic variations in the epidemiology of intrahepatic cholangiocarcinoma in the United States.美国肝内胆管癌流行病学中的种族和民族差异。
Liver Int. 2006 Nov;26(9):1047-53. doi: 10.1111/j.1478-3231.2006.01350.x.

胆管癌：来自泰国的经验教训。

Cholangiocarcinoma: lessons from Thailand.

作者信息

Sripa Banchob, Pairojkul Chawalit

机构信息

Department of Pathology, Faculty of Medicine, Thailand.

出版信息

Curr Opin Gastroenterol. 2008 May;24(3):349-56. doi: 10.1097/MOG.0b013e3282fbf9b3.

DOI:10.1097/MOG.0b013e3282fbf9b3
PMID:18408464
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4130346/
Abstract

PURPOSE OF REVIEW

To present the background of liver fluke-associated cholangiocarcinoma in Thailand focusing on recent epidemiological data and pathogenesis of this bile duct cancer.

RECENT FINDINGS

More systematic tumor registration in Thailand nowadays uncovers new high-incidence areas that are confined to not only the northeastern part but also some provinces in northern Thailand. The link between the liver fluke, Opisthorchis viverrini, and cholangiocarcinoma, particularly in terms of cellular and molecular pathogenesis, is further elucidated.

SUMMARY

Thailand is still the country with the highest incidence of cholangiocarcinoma in the world. Liver fluke induces chronic inflammation leading to oxidative DNA damage of the infected biliary epithelium and malignant transformation. Eradication of the fluke and identification of high-risk populations are urgently needed.

摘要

综述目的

介绍泰国肝吸虫相关胆管癌的背景，重点关注这种胆管癌的最新流行病学数据和发病机制。

最新发现

如今泰国更系统的肿瘤登记揭示了新的高发病区，这些地区不仅局限于东北部，还包括泰国北部的一些省份。肝吸虫华支睾吸虫与胆管癌之间的联系，特别是在细胞和分子发病机制方面，得到了进一步阐明。

总结

泰国仍然是世界上胆管癌发病率最高的国家。肝吸虫引发慢性炎症，导致受感染胆管上皮的氧化性DNA损伤和恶性转化。迫切需要根除肝吸虫并识别高危人群。