School of Dentistry, University of Birmingham, Birmingham, UK.
Arch Oral Biol. 2012 Feb;57(2):109-21. doi: 10.1016/j.archoralbio.2011.07.008.
As a mineralised connective tissue, dentine is well adapted to its functional role as a major structural component of the tooth. Although similar in composition to bone, dentine matrix is not remodelled physiologically and traditionally, has been regarded as a rather inert tissue. Nevertheless, dentine-pulp demonstrates strong regenerative potential which allows it to respond to disease and traumatic injury. Such responses are strongly influenced by cell-matrix interactions and modified by disease processes, including infection and inflammation. The identification of many bioactive molecules bound within dentine matrix has allowed their potential involvement in regenerative and other tissue responses to be better understood and new opportunities to be recognised for novel clinical therapies.
牙本质是一种矿化的结缔组织，非常适合作为牙齿主要结构成分的功能角色。尽管牙本质基质在组成上与骨相似，但它不会进行生理性重塑，传统上被认为是一种相对惰性的组织。然而，牙本质-牙髓具有很强的再生潜力，使其能够对疾病和创伤作出反应。这种反应受到细胞-基质相互作用的强烈影响，并被疾病过程改变，包括感染和炎症。许多结合在牙本质基质中的生物活性分子的鉴定，使人们更好地理解它们在再生和其他组织反应中的潜在作用，并为新的临床治疗方法提供了新的机会。
