Monash Centre of Cardiovascular Research and Education in Therapeutics, Monash University, Melbourne, VIC, Australia.
Lancet. 2011 Aug 20;378(9792):713-21. doi: 10.1016/S0140-6736(11)61038-6.
Understanding of contemporary pharmacological therapy for chronic heart failure continues to evolve. In this Review, we discuss how findings from clinical trials have caused the roles of old therapies to be expanded and past treatment algorithms to be challenged. Several trials investigating preserved ejection fraction as a measure of heart failure had disappointing results, although important studies are in progress. Many novel therapeutic approaches for heart failure have emerged and are discussed in this review. The pharmacological treatments for heart failure continue to change, with many exciting possibilities for the future.
对慢性心力衰竭的当代药理学治疗的理解仍在不断发展。在这篇综述中，我们讨论了临床试验的结果如何导致旧疗法的作用扩大和过去的治疗方案受到挑战。尽管正在进行重要的研究，但几项研究射血分数保留型心力衰竭的试验结果令人失望。在这篇综述中讨论了许多新的心力衰竭治疗方法。心力衰竭的药物治疗仍在不断变化，未来有许多令人兴奋的可能性。
