幽门螺杆菌感染与胃腺癌
Helicobacter pylori Infection and Gastric Adenocarcinoma.
作者信息
Correa Pelayo, Piazuelo M Blanca
机构信息
Anne Potter Wilson Professor of Medicine, Vanderbilt University School of Medicine, Nashville.
出版信息
US Gastroenterol Hepatol Rev. 2011 Jun;7(1):59-64.
Gastric adenocarcinoma is the second leading cause of cancer-related mortality worldwide. Infection with Helicobacter pylori is the strongest recognized risk factor for gastric adenocarcinoma. This bacterial species colonizes the stomach of more than half of the world's population; however, only a very small proportion of infected subjects develop adenocarcinoma. H. pylori causes a chronic gastritis that may last decades, and a multistep precancerous process is recognized for the most frequent histologic type of gastric adenocarcinoma: the intestinal type. The severity and long-term outcome of this infection is modulated by an increasing list of bacterial, host, and environmental factors, which interplay in a complex manner. Identification of individuals at high risk for gastric cancer that may enter a surveillance program and intervention during the precancerous process is the most suitable strategy for decreasing mortality due to this malignancy.
胃腺癌是全球癌症相关死亡的第二大主要原因。幽门螺杆菌感染是公认的胃腺癌最强风险因素。这种细菌在世界上超过一半人口的胃中定植；然而，只有极小比例的感染者会发展为腺癌。幽门螺杆菌会引发可能持续数十年的慢性胃炎，对于最常见的胃腺癌组织学类型——肠型，已确认存在一个多步骤的癌前过程。这种感染的严重程度和长期后果受到越来越多的细菌、宿主和环境因素的调节，这些因素以复杂的方式相互作用。识别可能进入监测程序并在癌前过程中进行干预的胃癌高危个体，是降低这种恶性肿瘤死亡率的最合适策略。
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