Department of Radiology, University of Vermont School of Medicine-FAHC, 111 Colchester Ave, Burlington, VT 05401, USA.
Pediatr Radiol. 2012 Feb;42(2):168-74. doi: 10.1007/s00247-011-2216-y. Epub 2011 Aug 21.
Optic pathway glioma (OPG) is a characteristic hallmark of neurofibromatosis type I (NF-I).
To evaluate the feasibility of magnetic resonance diffusion tensor imaging (MRDTI) at 3T to detect abnormalities of the optic nerves and optic radiations in children with NF-I.
3-T MRDTI was prospectively performed in 9 children with NF-I (7 boys, 2 girls, average age 7.8 years, range 3-17 years) and 44 controls (25 boys, 19 girls, average age 8.1 years, range 3-17 years). Fractional anisotropy (FA) and mean diffusivity were determined by region-of-interest analysis for the optic nerves and radiations. Statistical analysis compared controls to NF-I patients.
Two NF-I patients had bilateral optic nerve gliomas, three had chiasmatic gliomas and four had unidentified neurofibromatosis objects (UNOs) along the optic nerve pathways. All NF-I patients had statistically significant decreases in FA and elevations in mean diffusivity in the optic nerves and radiations compared to age-matched controls.
MRDTI can evaluate the optic pathways in children with NF-I. Statistically significant abnormalities were detected in the diffusion tensor metrics of the optic nerves and radiations in children with NF-I compared to age-matched controls.
视神经胶质瘤（OPG）是神经纤维瘤病 1 型（NF-I）的特征标志。
评估 3T 磁共振扩散张量成像（MRDTI）检测 NF-I 儿童视神经和视辐射异常的可行性。
前瞻性纳入 9 例 NF-I 患儿（7 名男孩，2 名女孩，平均年龄 7.8 岁，范围 3-17 岁）和 44 例对照者（25 名男孩，19 名女孩，平均年龄 8.1 岁，范围 3-17 岁）进行 3T MRDTI 检查。采用感兴趣区分析方法测定视神经和视辐射的各向异性分数（FA）和平均弥散度。对 NF-I 患儿与对照组进行统计学分析。
2 例 NF-I 患儿双侧视神经胶质瘤，3 例视交叉胶质瘤，4 例视神经通路不明神经纤维瘤（UNO）。与年龄匹配的对照组相比，所有 NF-I 患儿的视神经和视辐射的 FA 均显著降低，平均弥散度升高。
MRDTI 可用于评估 NF-I 患儿的视神经通路。与年龄匹配的对照组相比，NF-I 患儿视神经和视辐射的弥散张量指标存在统计学显著异常。
