通过对映选择性 N-酰化拆分β-内酰胺。
Kinetic resolution of β-lactams via enantioselective N-acylation.
机构信息
Department of Chemistry, Washington University, Campus Box 1134, One Brookings Drive, St. Louis, Missouri 63130, USA.
出版信息
Org Lett. 2011 Sep 16;13(18):4755-7. doi: 10.1021/ol201911z. Epub 2011 Aug 22.
PMID:21859115
Abstract
Enantioselective N-acylation of 4-aryl-β-lactams in the presence of acyl transfer catalyst Cl-PIQ provides an effective method for their non-enzymatic kinetic resolution.
摘要
在酰基转移催化剂 Cl-PIQ 的存在下，对 4-芳基-β-内酰胺进行对映选择性 N-酰化，为它们的非酶动力学拆分提供了一种有效的方法。
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