Department of Chemistry, Washington University, St. Louis, Missouri 63130, United States.
J Am Chem Soc. 2011 Sep 7;133(35):13902-5. doi: 10.1021/ja2058633. Epub 2011 Aug 12.
The first nonenzymatic kinetic resolution of β-lactams has been achieved. Alcoholysis of their N-aroyl derivatives in the presence of a simple chiral acyl transfer catalyst, benzotetramisole, produces β-amino acid derivatives with excellent enantioselectivity.
首次实现了β-内酰胺的非酶动力学拆分。在简单的手性酰基转移催化剂苯并四唑的存在下，β-内酰胺的 N-芳酰衍生物进行醇解反应，生成具有优异对映选择性的β-氨基酸衍生物。
