Department of Biomedical Science, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, 50300 Kuala Lumpur, Malaysia.
Nat Prod Res. 2012;26(7):684-9. doi: 10.1080/14786419.2010.545354. Epub 2011 Aug 23.
Stichopus hermanni and Stichopus vastus are sea cucumber species from the Stichopodidae family within the coastal waters of Malaysia. The integument of these invertebrates is hypothesised to contain abundant glycosaminoglycans (GAGs). GAGs are divided into non-sulphated and sulphated GAGs. Sulphated GAGs have various chemico-biological functions that are beneficial to humans. This study quantitatively analysed N-, O-sulphated and total sulphated GAG content from three different anatomical regions (integument, internal organs and coelomic fluid) of S. hermanni and S. vastus. The integument revealed the highest content of total, O- and N-sulphated GAGs, followed by the internal organs and the coelomic fluid for both species of sea cucumbers. The percentage division of O- and N-sulphated GAGs suggested that anatomical parts of both species showed higher levels of O-sulphated GAGs compared to N-sulphated GAGs. In conclusion, these findings indicate that the integument body wall of S. hermanni and S. vastus is a rich source of sulphated GAGs.
糙海参和糙刺参是来自马来西亚沿海水域的海参科物种。这些无脊椎动物的表皮被假设含有丰富的糖胺聚糖（GAGs）。GAGs 分为非硫酸化和硫酸化 GAGs。硫酸化 GAGs 具有多种有益于人类的化学和生物学功能。本研究定量分析了糙海参和糙刺参三个不同解剖部位（表皮、内脏器官和体腔液）的 N-、O-硫酸化和总硫酸化 GAG 含量。表皮显示出最高的总、O-和 N-硫酸化 GAG 含量，其次是内脏器官和体腔液，这两种海参均如此。O-和 N-硫酸化 GAG 的百分比分配表明，与 N-硫酸化 GAG 相比，两种物种的解剖部位均显示出更高水平的 O-硫酸化 GAG。总之，这些发现表明糙海参和糙刺参的体壁表皮是硫酸化 GAG 的丰富来源。
