Service de Bactériologie-Virologie, Hôpital de Bicêtre, 78 rue du Général Leclerc, 94275 Le-Kremlin-Bicêtre cedex, France.
Antimicrob Agents Chemother. 2011 Nov;55(11):5403-7. doi: 10.1128/AAC.00585-11. Epub 2011 Aug 22.
Genetic features associated with the bla(NDM-1) gene were investigated in 6 Escherichia coli, 7 Klebsiella pneumoniae, 1 Citrobacter freundii, 1 Proteus mirabilis, and 1 Providencia stuartii isolate of worldwide origin. Clonal diversity was observed for both E. coli and K. pneumoniae. The bla(NDM-1) gene was carried by different plasmid types (IncA/C, IncF, IncL/M, or untypeable) and was likely chromosome borne in two isolates. The bla(NDM-1) plasmids coharbored a variety of resistance determinants, including β-lactamase genes, quinolone resistance genes, and 16S RNA methylase genes.
对源自世界各地的 6 株大肠埃希菌、7 株肺炎克雷伯菌、1 株弗氏柠檬酸杆菌、1 株奇异变形杆菌和 1 株斯氏普罗威登斯菌中与 bla(NDM-1)基因相关的遗传特征进行了研究。观察到大肠埃希菌和肺炎克雷伯菌的克隆多样性。bla(NDM-1)基因由不同的质粒类型（IncA/C、IncF、IncL/M 或无法分型）携带，并且在两个分离株中可能是染色体携带的。bla(NDM-1)质粒共同携带多种耐药决定因子，包括β-内酰胺酶基因、喹诺酮类耐药基因和 16S RNA 甲基化酶基因。
