突尼斯大肠杆菌、肺炎克雷伯菌和奇异变形杆菌中多种AmpC β-内酰胺酶的共现情况
Cooccurrence of Multiple AmpC β-Lactamases in Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis in Tunisia.
作者信息
Chérif Thouraya, Saidani Mabrouka, Decré Dominique, Boutiba-Ben Boubaker Ilhem, Arlet Guillaume
机构信息
Université de Tunis El Manar, Faculté de Médecine de Tunis, LR99ES09 Laboratoire de Résistance aux Antimicrobiens, Tunis, Tunisie.
Université de Tunis El Manar, Faculté de Médecine de Tunis, LR99ES09 Laboratoire de Résistance aux Antimicrobiens, Tunis, Tunisie CHU Charles Nicolle, Service de Microbiologie, Tunis, Tunisia.
出版信息
Antimicrob Agents Chemother. 2015 Oct 12;60(1):44-51. doi: 10.1128/AAC.00828-15. Print 2016 Jan.
Abstract
Over a period of 40 months, plasmid-mediated AmpC β-lactamases were detected in Tunis, Tunisia, in 78 isolates (0.59%) of Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis. In 67 isolates, only one ampC gene was detected, i.e., blaCMY-2-type (n = 33), blaACC (n = 23), blaDHA (n = 6) or blaEBC (n = 5). Multiple ampC genes were detected in 11 isolates, with the following distribution: blaMOX-2, blaFOX-3, and blaCMY-4/16 (n = 6), blaFOX-3 and blaMOX-2 (n = 3), and blaCMY-4 and blaMOX-2 (n = 2). A great variety of plasmids carrying these genes was found, independently of the species and the bla gene. If the genetic context of blaCMY-2-type is variable, that of blaMOX-2, reported in part previously, is unique and that of blaFOX-3 is unique and new.
摘要
在40个月的时间里，在突尼斯突尼斯市从78株大肠杆菌、肺炎克雷伯菌和奇异变形杆菌中检测到质粒介导的AmpC β-内酰胺酶（占0.59%）。在67株菌株中，仅检测到一个ampC基因，即blaCMY-2型（n = 33）、blaACC（n = 23）、blaDHA（n = 6）或blaEBC（n = 5）。在11株菌株中检测到多个ampC基因，其分布如下：blaMOX-2、blaFOX-3和blaCMY-4/16（n = 6），blaFOX-3和blaMOX-2（n = 3），以及blaCMY-4和blaMOX-2（n = 2）。发现了携带这些基因的多种质粒，与物种和bla基因无关。如果blaCMY-2型的基因背景是可变的，那么之前部分报道的blaMOX-2的基因背景是独特的，而blaFOX-3的基因背景是独特且新颖的。
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