LRF Virus Centre, MRC and University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Cancer Epidemiol Biomarkers Prev. 2011 Oct;20(10):2232-6. doi: 10.1158/1055-9965.EPI-11-0561. Epub 2011 Aug 22.
A novel retrovirus, xenotropic murine leukemia virus-related virus (XMRV), has been detected in prostate cancer samples and in peripheral blood mononuclear cells (PBMC) from patients with chronic fatigue syndrome. In addition, the virus has been identified in PBMCs from healthy controls. These data suggest that XMRV is circulating in the human population. XMRV is closely related to murine leukemia viruses, which cause lymphoid malignancies in mice. The aim of this study was to determine whether XMRV is directly associated with common forms of human lymphoma or leukemia.
DNA samples from 368 patients with lymphoid malignancies and 139 patients with benign lymphadenopathy or other malignant disease were screened for XMRV, using three specific and sensitive quantitative PCR assays.
XMRV was not detected in any sample using any of the three assays.
The data suggest that this virus is not directly involved in the pathogenesis of common types of lymphoid malignancy and that XMRV is not a prevalent blood borne infection, at least in the United Kingdom.
There is no evidence that XMRV is associated with lymphoid malignancies, and further studies should resolve inconsistencies in results of studies examining XMRV prevalence.
一种新型逆转录病毒，即嗜性鼠白血病病毒相关病毒（XMRV），已在前列腺癌样本和慢性疲劳综合征患者的外周血单个核细胞（PBMC）中检测到。此外，该病毒已在健康对照者的 PBMC 中被识别。这些数据表明 XMRV 在人群中循环。XMRV 与引起小鼠淋巴样恶性肿瘤的鼠白血病病毒密切相关。本研究旨在确定 XMRV 是否与人类常见的淋巴瘤或白血病形式直接相关。
使用三种特异性和敏感的定量 PCR 检测法，对 368 例淋巴样恶性肿瘤患者和 139 例良性淋巴结病或其他恶性疾病患者的 DNA 样本进行 XMRV 筛查。
在使用三种检测方法的任何一种时，均未在任何样本中检测到 XMRV。
这些数据表明，该病毒未直接参与常见类型的淋巴样恶性肿瘤的发病机制，而且 XMRV 不是普遍存在的血源感染，至少在英国不是。
没有证据表明 XMRV 与淋巴样恶性肿瘤有关，进一步的研究应解决检查 XMRV 流行率的研究结果中的不一致之处。
