Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Nat Rev Urol. 2012 Jan 10;9(2):111-8. doi: 10.1038/nrurol.2011.225.
XMRV was first described in 2006, when it was identified in samples isolated from prostate cancer tissues. However, studies have since shown that XMRV arose in the laboratory and was formed by genetic recombination between two viral genomes carried in the germline DNA of mice used during serial transplantation of the CWR22 prostate cancer xenograft. These new findings strongly imply that XMRV does not circulate in humans, but is only present in the laboratory. Thus, there is no reason to believe that it has any role in the etiology of prostate cancer or other diseases.
XMRV 于 2006 年首次被描述，当时它被发现在从前列腺癌组织中分离的样本中。然而，此后的研究表明，XMRV 是在实验室中产生的，是由在连续移植 CWR22 前列腺癌异种移植物过程中使用的小鼠种系 DNA 中携带的两种病毒基因组之间的遗传重组形成的。这些新发现强烈暗示 XMRV 不会在人类中传播，而只存在于实验室中。因此，没有理由认为它在前列腺癌或其他疾病的病因学中起任何作用。
