Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark.
Division for Diet, Disease Prevention and Toxicology, National Food Institute, Technical University of Denmark, Kgs. Lyngby, Denmark.
PLoS One. 2018 Aug 22;13(8):e0202363. doi: 10.1371/journal.pone.0202363. eCollection 2018.
The risk of coronary heart disease associated with intake of individual trans fatty acids (TFAs) is not clear. Adipose tissue content of TFAs is a biomarker of TFA intake and metabolism.
We investigated the rate of myocardial infarction (MI) associated with the adipose tissue content of total 18:1t, isomers of 18:1t (18:1 Δ6-10t and 18:1 Δ11t) and 18:2 Δ9c, 11t.
A case-cohort study, nested within the Danish Diet, Cancer and Health cohort (n = 57,053), was conducted, which included a random sample (n = 3156) of the total cohort and all incident MI cases (n = 2148) during follow-up (14 years). Information on MI cases was obtained by linkage with nationwide registers and validated. Adipose tissue was taken from the participants buttocks and the fatty acid composition was determined by gas chromatography.
Women with higher adipose tissue content of total 18:1t had a 57% higher MI rate (quintiles 5 versus 1, hazard ratio, 1.57; 95% confidence interval, 1.12-2.20; P-trend = 0.011) and women with higher content of 18:1 Δ6-10t had a 76% higher MI rate (quintiles 5 versus 1, hazard ratio, 1.76; 95% confidence interval, 1.23-2.51; P-trend = 0.002). No association between 18:1 Δ11t content and MI rate was observed. In men, no associations between adipose tissue content of total 18:1t and 18:1 Δ6-10t and MI rate were observed. However, men with higher content of 18:1 Δ11t had a 48% higher MI rate (quintiles 5 versus 1, hazard ratio, 1.48; 95% confidence interval, 1.17-1.86; P-trend = 0.003). Adipose tissue content of 18:2 Δ9c, 11t was not associated with MI rate in women or men.
Adipose tissue content of 18:2 Δ9c, 11t was not associated with MI rate in women or men, whereas higher contents of isomers of 18:1t were associated with higher MI rates but the associations for individual 18:1t isomers differed, however, in women and men.
摄入不同种类的反式脂肪酸与冠心病的风险关系尚不明确。脂肪组织中的反式脂肪酸含量是摄入和代谢反式脂肪酸的生物标志物。
我们旨在研究脂肪组织中总 18:1t、18:1t 的异构体（18:1 Δ6-10t 和 18:1 Δ11t）和 18:2 Δ9c、11t 含量与心肌梗死（MI）风险之间的关系。
采用丹麦饮食、癌症与健康队列（n=57053）中的病例-队列研究，该研究包括对总队列的随机样本（n=3156）和随访期间（14 年）所有发生的 MI 病例（n=2148）进行嵌套。通过与全国性登记处的链接获取 MI 病例信息，并对其进行验证。从参与者的臀部采集脂肪组织，并通过气相色谱法测定脂肪酸组成。
与总 18:1t 脂肪组织含量最低的五分位数（1 分位）相比，18:1t 脂肪组织含量最高的五分位数（5 分位）女性的 MI 发生率高出 57%（危险比，1.57；95%置信区间，1.12-2.20；P 趋势=0.011），18:1 Δ6-10t 含量最高的五分位数（5 分位）女性的 MI 发生率高出 76%（危险比，1.76；95%置信区间，1.23-2.51；P 趋势=0.002）。男性脂肪组织中总 18:1t 和 18:1 Δ6-10t 含量与 MI 发生率之间未见相关性。然而，18:1 Δ11t 含量较高的男性 MI 发生率高出 48%（五分位数 5 比 1，危险比 1.48；95%置信区间 1.17-1.86；P 趋势=0.003）。18:2 Δ9c、11t 脂肪组织含量与女性或男性的 MI 发生率无关。
女性或男性脂肪组织中 18:2 Δ9c、11t 含量与 MI 发生率无关，而 18:1t 异构体的含量与 MI 发生率较高有关，但不同 18:1t 异构体的相关性在女性和男性中有所不同。
