Department of Cardiology, Aalborg University Hospital, Søndre Skovvej 15, 9000, Aalborg, Denmark.
Department of Vascular Surgery, Aalborg University Hospital, Aalborg, Denmark.
Eur J Nutr. 2020 Oct;59(7):3191-3200. doi: 10.1007/s00394-019-02159-2. Epub 2019 Dec 12.
The aim of this study was to investigate the association between adipose tissue content of the plant-derived n-3 fatty acid, alpha-linolenic acid, and the rate of incident peripheral artery disease (PAD).
We conducted a case-cohort study nested within the Danish Diet, Cancer and Health cohort (n = 57,053), which was established between 1993 and 1997. Potential PAD cases were identified using linkage with The Danish National Patient Register and all potential cases were validated. Adipose tissue samples from the buttock were collected at baseline and fatty acid composition was determined in cases and in a random sample (n = 3500) from the cohort by gas chromatography. Statistical analyses were performed using weighted Cox regression allowing for different baseline hazards among sexes.
During a median of 13.5 years of follow-up, we identified 863 PAD cases with complete information. The median adipose tissue content of ALA in the sub-cohort (n = 3197) was 0.84% (interquartile range 0.73-0.94%) of total fatty acids. In multivariate analyses including adjustment for established risk factors, we observed a U-shaped association between ALA in adipose tissue and rate of PAD, but the association was not statistically significant (P = 0.131). Similar pattern of associations were observed between ALA content in adipose tissue and the rate of PAD among men and women.
We found indications of a U-shaped association between adipose tissue content of ALA and the rate of PAD, but the association was not statistically significant.
本研究旨在探讨植物源性 n-3 脂肪酸 α-亚麻酸（ALA）在脂肪组织中的含量与外周动脉疾病（PAD）发生率之间的关系。
我们进行了一项病例-队列研究，该研究嵌套在丹麦饮食、癌症和健康队列（n=57053）中，该队列成立于 1993 年至 1997 年之间。通过与丹麦国家患者登记处的关联来确定潜在的 PAD 病例，并对所有潜在病例进行验证。在基线时从臀部采集脂肪组织样本，并通过气相色谱法在病例和队列中的随机样本（n=3500）中确定脂肪酸组成。使用加权 Cox 回归进行统计分析，允许性别之间存在不同的基线风险。
在中位数为 13.5 年的随访期间，我们确定了 863 例具有完整信息的 PAD 病例。在亚队列（n=3197）中，ALA 在脂肪组织中的中位数为总脂肪酸的 0.84%（四分位距 0.73-0.94%）。在包括调整既定危险因素的多变量分析中，我们观察到 ALA 在脂肪组织中与 PAD 发生率之间存在 U 形关联，但关联无统计学意义（P=0.131）。在男性和女性中，也观察到了脂肪组织中 ALA 含量与 PAD 发生率之间类似的关联模式。
我们发现 ALA 在脂肪组织中的含量与 PAD 发生率之间存在 U 形关联的迹象，但关联无统计学意义。
