MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China.
Small. 2011 Oct 4;7(19):2727-35. doi: 10.1002/smll.201100669. Epub 2011 Aug 22.
Nanomaterials have recently attracted much attention as efficient transducers for cancer photothermal therapy, based on their intrinsic absorption properties in the near-infrared region. This study explores a novel therapy model with mitochondria-targeting single-walled carbon nanotubes (SWNTs), which act efficiently to convert 980-nm laser energy into heat and selectively destroy the target mitochondria, thereby inducing mitochondrial depolarization, cytochrome c release, and caspase 3 activation. The laser+SWNTs process affords remarkable efficacy in suppressing tumor growth in a breast cancer model, and results in complete tumor regression in some cases. Laser+SWNTs could prove to be a promising selective local treatment modality, while minimizing adverse side effects.
纳米材料由于在近红外区域具有固有吸收特性，最近作为癌症光热治疗的有效换能器引起了广泛关注。本研究探索了一种新型的治疗模型，使用靶向线粒体的单壁碳纳米管 (SWNTs)，它可以有效地将 980nm 激光能量转化为热能，并选择性地破坏目标线粒体，从而导致线粒体去极化、细胞色素 c 释放和 caspase 3 激活。激光+SWNTs 过程在乳腺癌模型中显著抑制肿瘤生长，并在某些情况下导致完全肿瘤消退。激光+SWNTs 可能成为一种有前途的选择性局部治疗方式，同时最大限度地减少不良反应。
