Institute for Materials Chemistry and Engineering, Kyushu University, Kasuga-shi, Fukuoka 816-8580, Japan.
Org Lett. 2011 Sep 16;13(18):4926-9. doi: 10.1021/ol202009x. Epub 2011 Aug 23.
Intermolecular reactions of planar chiral 9-membered diallylic amides provide a variety of bicyclic compounds with central chiralities in a stereospecific fashion with high group selectivity. Lewis-acid-promoted intramolecular reactions of the obtained bicyclic compounds provide transannular products in a stereospecific fashion. Furthermore, a direct transannular reaction of diallylic amide involving sequential intermolecular-intramolecular reactions has been developed.
平面手性 9 元烯丙基酰胺的分子间反应以高基团选择性的立体特异性方式提供了各种具有中心手性的双环化合物。所得到的双环化合物的路易斯酸促进的分子内反应以立体特异性方式提供了反环产物。此外，还开发了涉及顺序的分子间-分子内反应的烯丙基酰胺的直接反环反应。
